Effect of Deep Sedation on Mechanical Power in Moderate to Severe Acute Respiratory Distress Syndrome: A Prospective Self-Control Study.
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
12
2019
revised:
16
03
2020
accepted:
30
03
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
11
2
2021
Statut:
epublish
Résumé
Mechanical power (MP) is a parameter for assessing ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Deep sedation inhibits the respiratory center and reduces the excessive spontaneous breathing in ARDS patients, thereby reducing transpulmonary pressure (Ptp) and lung injury. However, the effect of sedation on MP in ARDS patients is not yet clear. Therefore, the purpose of this study was to investigate the effect of deep sedation on MP in ARDS patients. Patients with moderate to severe ARDS who required mechanical ventilation were considered. Different degrees of sedation were performed on patients in three stages after 24 hours of mechanical ventilation. The three stages are as follows: stage 1 (H+3): 0 to 3 hours of sedation; patients' Ramsay score was 2-3 to obtain mild sedation; stage 2 (H+6): 4 to 6 hours of sedation; the sedation depth was adjusted to 5-6 points; and stage 3 (H+9): 7 to 9 hours of sedation; the sedation depth was adjusted to 2-3 points. Under deep sedation (H+6), MP, respiratory rate (RR), and Ptp were significantly lower than the ones in the patients under mild sedation (H+3) (all
Identifiants
pubmed: 32351988
doi: 10.1155/2020/2729354
pmc: PMC7174918
doi:
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2729354Informations de copyright
Copyright © 2020 Yongpeng Xie et al.
Déclaration de conflit d'intérêts
All the authors declare that they have no conflicts of interest.
Références
Am J Respir Crit Care Med. 2017 Jun 1;195(11):1429-1438
pubmed: 28146639
Ann Am Thorac Soc. 2019 Oct;16(10):1263-1272
pubmed: 31247145
Crit Care. 2019 Jun 13;23(1):217
pubmed: 31196203
Expert Rev Respir Med. 2019 Aug;13(8):737-746
pubmed: 31274034
Am J Respir Crit Care Med. 2018 Jul 1;198(1):77-89
pubmed: 29373802
Crit Care. 2017 Jul 12;21(1):183
pubmed: 28701178
Am J Respir Crit Care Med. 2017 Oct 15;196(8):964-984
pubmed: 28406724
Physiol Meas. 2017 Nov 30;38(12):R280-H303
pubmed: 28967868
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Front Physiol. 2018 Apr 04;9:318
pubmed: 29670537
Respir Care. 2018 Jan;63(1):1-10
pubmed: 29018041
Crit Care Nurs Q. 2019 Oct/Dec;42(4):376-391
pubmed: 31449148
Respir Care. 2018 Apr;63(4):441-447
pubmed: 29233852
Intensive Care Med. 2018 Nov;44(11):1914-1922
pubmed: 30291378
JAMA. 2018 Feb 20;319(7):711-712
pubmed: 29466577
Ann Transl Med. 2017 Jul;5(14):285
pubmed: 28828360
N Engl J Med. 2017 Aug 10;377(6):562-572
pubmed: 28792873
Intensive Care Med. 2016 Oct;42(10):1567-1575
pubmed: 27620287
Dimens Crit Care Nurs. 2019 Mar/Apr;38(2):90-95
pubmed: 30702478
Expert Rev Respir Med. 2018 May;12(5):403-414
pubmed: 29575957
Medicine (Baltimore). 2019 Jul;98(29):e16531
pubmed: 31335733
Anaesthesist. 2017 Jul;66(7):539-552
pubmed: 28677019
Anesthesiology. 2016 May;124(5):1100-8
pubmed: 26872367
Am J Respir Crit Care Med. 2017 Feb 15;195(4):438-442
pubmed: 27626833
Ann Transl Med. 2017 Jul;5(14):291
pubmed: 28828366
Curr Opin Crit Care. 2016 Feb;22(1):7-13
pubmed: 26627536
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Jun;31(6):704-708
pubmed: 31315727
Anesthesiology. 2018 Jun;128(6):1187-1192
pubmed: 29521672
Ann Transl Med. 2017 Jul;5(14):286
pubmed: 28828361