A novel drug delivery system obtained from hydrophobic modified amphiphilic polymers by Maillard reaction.

Drug Carriers / chemistry Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Maillard Reaction Paclitaxel / chemistry Polymers / chemistry
Amphiphilic Hot water pretreatment Hydrophobic modified Maillard reaction Paclitaxel

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
15 Aug 2020
Historique:
received: 09 02 2020
revised: 30 03 2020
accepted: 24 04 2020
pubmed: 1 5 2020
medline: 9 3 2021
entrez: 1 5 2020
Statut: ppublish

Résumé

In order to improve the bioavailability of paclitaxel, hemicellulose fractions from hot water pretreatment liquor were the first time to design new amphiphilic polymers through the Maillard reaction. Structural characteristics, emulsifying and drug release behaviors of the amphiphilic polymers were then investigated in detail. Results showed that the amphiphilic polymers with degrees of substitution ranging from 0.31 to 1.65 were obtained by reacting hemicellulose fractions with dodecylamine. Furthermore, the nanometer paclitaxel emusion was successfully preparaed. The amphiphilic polymer provided excellent emulsifying properties and desired storage stability. The average particle sizes of emulsion stayed in the range of 235-266 nm, even after 90 days of storage. Besides, the amphiphilic polymer also proved considerable paclitaxel preservation ability and released performance of pH-responsive. The controlled release of paclitaxel was better at pH 5.0, and thus the new amphiphilic polymer can be used as a delivery carrier of hydrophobic drugs.

Identifiants

DOI: 10.1016/j.ijbiomac.2020.04.218 PMID: 32353493
pubmed: 32353493
pii: S0141-8130(20)33085-3
doi: 10.1016/j.ijbiomac.2020.04.218
pii:
doi:

Substances chimiques

Drug Carriers 0
Polymers 0
Paclitaxel P88XT4IS4D

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

146-150

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Nianjie Feng (N)

Hubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center of Green Lightweight Materials and Processing, Hubei University of Technology, Wuhan 430068, China; Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing 100048, China.

Hua Wu (H)

Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing 100048, China.

Yimin Xie (Y)

Hubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center of Green Lightweight Materials and Processing, Hubei University of Technology, Wuhan 430068, China.

Qian Wu (Q)

Hubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center of Green Lightweight Materials and Processing, Hubei University of Technology, Wuhan 430068, China; Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratoy of Industrial Microbiology, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Research Center of Food Fermentation Engineering and Technology, Hubei University of Technology, Wuhan, Hubei 430068, China. Electronic address: qianwill2007@163.com.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › A novel drug delivery system obtained from...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › A novel drug delivery system obtained from...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › A novel drug delivery system obtained from...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Réaction de Maillard › A novel drug delivery system obtained from...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Taxoïdes › Paclitaxel › A novel drug delivery system obtained from...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › A novel drug delivery system obtained from...