Characteristics of adult- compared to childhood-onset type 1 diabetes.
Adolescent
Adult
Age of Onset
Blood Glucose Self-Monitoring
Child
Cholesterol, HDL
/ blood
Cholesterol, LDL
/ blood
Diabetes Mellitus, Type 1
/ drug therapy
Female
Glycated Hemoglobin
/ metabolism
Humans
Hypoglycemic Agents
/ therapeutic use
Infusion Pumps, Implantable
Insulin
/ therapeutic use
Insulin Infusion Systems
Male
Triglycerides
/ blood
Young Adult
Journal
Diabetic medicine : a journal of the British Diabetic Association
ISSN: 1464-5491
Titre abrégé: Diabet Med
Pays: England
ID NLM: 8500858
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
accepted:
27
04
2020
pubmed:
1
5
2020
medline:
30
10
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
To compare diagnosis characteristics, diabetes management and comorbidities in a population diagnosed with type 1 diabetes in childhood with those in a similar population diagnosed in adulthood to identify disease differences related to the age of diabetes onset. This analysis was performed using the T1D Exchange Clinic Registry, a cross-sectional survivor cohort. Retrospectively collected characteristics were compared across the following age-at-diagnosis groups: <10, 10-17, 18-24, 25-39 and ≥40 years. The entire cohort included 20 660 participants [51% female, median (interquartile range) age 18 (14-36) years, 82% non-Hispanic white]. Diabetic ketoacidosis at diagnosis was more common among those with onset in childhood. Participants diagnosed as adults were more likely to be overweight/obese at diagnosis and to have used oral agents preceding type 1 diabetes diagnosis (57%). Current insulin pump use was less frequent in participants diagnosed at older ages. Current glycaemic control, measured by HbA These results show differences and similarities between type 1 diabetes diagnosed in childhood vs adulthood; notably, there was a tendency for there was a higher frequency of diabetic ketoacidosis at onset in children and a higher frequency of use of oral antidiabetes agents in adults. The data indicate that there is little distinction between the clinical characteristics and outcomes of type 1 diabetes diagnosed in childhood vs adulthood. Optimizing glycaemic control remains a challenge in all age groups, with lower use of insulin pumps impacting those diagnosed as adults.
Substances chimiques
Cholesterol, HDL
0
Cholesterol, LDL
0
Glycated Hemoglobin A
0
Hypoglycemic Agents
0
Insulin
0
Triglycerides
0
hemoglobin A1c protein, human
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2109-2115Subventions
Organisme : Leona M. and Harry B. Helmsley Charitable Trust
Pays : International
Informations de copyright
© 2020 Diabetes UK.
Références
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