Interleukin-13 drives metabolic conditioning of muscle to endurance exercise.

Adaptation, Physiological / immunology Animals Blood Glucose / metabolism Cell Line Fatty Acids / metabolism Female Glycogen / metabolism Humans Interleukin-13 / blood Interleukin-13 Receptor alpha1 Subunit / genetics Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria, Muscle / metabolism Muscle, Skeletal / metabolism Myoblasts / metabolism Oxidation-Reduction Physical Conditioning, Animal Physical Endurance / immunology Running STAT3 Transcription Factor / genetics

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
01 05 2020
Historique:
received: 22 02 2018
revised: 18 02 2020
accepted: 17 03 2020
entrez: 2 5 2020
pubmed: 2 5 2020
medline: 13 5 2020
Statut: ppublish

Résumé

Repeated bouts of exercise condition muscle mitochondria to meet increased energy demand-an adaptive response associated with improved metabolic fitness. We found that the type 2 cytokine interleukin-13 (IL-13) is induced in exercising muscle, where it orchestrates metabolic reprogramming that preserves glycogen in favor of fatty acid oxidation and mitochondrial respiration. Exercise training-mediated mitochondrial biogenesis, running endurance, and beneficial glycemic effects were lost in

Identifiants

DOI: 10.1126/science.aat3987 PMID: 32355002 PMC: PMC7549736
pubmed: 32355002
pii: 368/6490/eaat3987
doi: 10.1126/science.aat3987
pmc: PMC7549736
mid: NIHMS1635214
pii:
doi:

Substances chimiques

Blood Glucose 0
Fatty Acids 0
Interleukin-13 0
Interleukin-13 Receptor alpha1 Subunit 0
STAT3 Transcription Factor 0
Stat3 protein, mouse 0
Glycogen 9005-79-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK113791
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK107256
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI131659
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129191
Pays : United States
Organisme : NIGMS NIH HHS
ID : F31 GM117854
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Références

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Auteurs

Nelson H Knudsen (NH)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0002-0384-1097

Kristopher J Stanya (KJ)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0002-5369-729X

Alexander L Hyde (AL)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

Mayer M Chalom (MM)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0001-7852-9586

Ryan K Alexander (RK)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0002-9204-9586

Yae-Huei Liou (YH)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0001-6758-7318

Kyle A Starost (KA)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0003-4705-958X

Matthew R Gangl (MR)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

David Jacobi (D)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0001-8674-223X

Sihao Liu (S)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

Danesh H Sopariwala (DH)

Metabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas McGovern Medical School, Houston, TX 77030, USA.

Diogo Fonseca-Pereira (D)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0002-7400-9804

Jun Li (J)

Department of Nutrition and Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0003-3519-8638

Frank B Hu (FB)

Department of Nutrition and Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Wendy S Garrett (WS)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0002-5092-0150

Vihang A Narkar (VA)

Metabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas McGovern Medical School, Houston, TX 77030, USA.
ORCID: 0000-0001-5574-083X

Eric A Ortlund (EA)

Emory University School of Medicine, Atlanta, GA 30322, USA.
ORCID: 0000-0001-8855-3029

Jonathan H Kim (JH)

Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory Clinical Cardiovascular Research Institute, Atlanta, GA 30322, USA.

Chad M Paton (CM)

Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA.
ORCID: 0000-0001-8356-5303

Jamie A Cooper (JA)

Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA.

Chih-Hao Lee (CH)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. clee@hsph.harvard.edu.
ORCID: 0000-0002-6090-0786

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Eucaryotes › Animaux › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Lipides › Acides gras › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Glycogène › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-13 › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-13 › Récepteur à l'interleukine-4 de type II › Sous-unité alpha1 du récepteur à l'interleukine-13 › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Cellules › Cellules souches › Myoblastes › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Conditionnement physique d'animal › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Performance sportive › Endurance physique › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Course à pied › Interleukin-13 drives metabolic conditioning...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › Interleukin-13 drives metabolic conditioning...