Construction and Preclinical Evaluation of a

Animals Blotting, Western Cell Line, Tumor Female Flow Cytometry GPI-Linked Proteins / metabolism Humans Immunohistochemistry Iodine Isotopes / analysis Mesothelin Mice, Inbred BALB C Neoplasms / diagnostic imaging Positron-Emission Tomography Radioimmunodetection Radiometry
iodine isotope mesothelin positron emission tomography radioimmunoimaging scFv-Fc

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
01 06 2020
Historique:
pubmed: 2 5 2020
medline: 8 6 2021
entrez: 2 5 2020
Statut: ppublish

Résumé

Mesothelin is a molecular biomarker of many types of solid cancers, which may represent a highly promising new target in the development of cancer-targeted diagnostic agents. A human anti-mesothelin antibody with a low molecular weight, ET210sc, was applied; this antibody has potent affinity and can penetrate tissue quickly and stably without causing immunoreactions. We developed a new

Identifiants

DOI: 10.1021/acs.molpharmaceut.9b01281 PMID: 32356995
pubmed: 32356995
doi: 10.1021/acs.molpharmaceut.9b01281
doi:

Substances chimiques

GPI-Linked Proteins 0
Iodine Isotopes 0
Msln protein, mouse 0
Mesothelin J27WDC343N

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1875-1883

Auteurs

Xudong Wang (X)

State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871, China.

Feng Wang (F)

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Jintao Han (J)

State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871, China.

Zhi Yang (Z)

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
ORCID: 0000-0003-2084-5193

Hua Zhu (H)

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
ORCID: 0000-0002-4198-5809

Gen Yang (G)

State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Immunotransfert › Technique de Western › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Protéines liées au GPI › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Isotopes de l'iode › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Mésothéline › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Tumeurs › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Radioimmunodétection › Construction and Preclinical Evaluation of a
questionsmedicales.fr › Techniques d'investigation › Radiométrie › Construction and Preclinical Evaluation of a