High-intensity swimming exercise reduces inflammatory pain in mice by activation of the endocannabinoid system.
cannabinoid receptors
chronic pain
inflammatory pain
physical exercise
Journal
Scandinavian journal of medicine & science in sports
ISSN: 1600-0838
Titre abrégé: Scand J Med Sci Sports
Pays: Denmark
ID NLM: 9111504
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
04
10
2019
revised:
08
03
2020
accepted:
15
04
2020
pubmed:
3
5
2020
medline:
10
2
2021
entrez:
3
5
2020
Statut:
ppublish
Résumé
As exercise intervention solely for pain reduction is relatively new, the available research still leaves an incomplete picture of responsible mechanisms and pathways. Nonetheless, evidence indicates that exercise-induced analgesia involves activation of the endocannabinoid (eCB) system. The present study investigated the role of the eCB system on the antihyperalgesic effect of high-intensity swimming exercise (HISE) in an animal model of peripheral persistent inflammation. Male Swiss mice were allocated to non-exercised and exercised groups and subjected to subcutaneous intraplantar injection (i.pl.) of a single dose of complete Freund's adjuvant (CFA) to induce inflammatory pain. Cumulative HISE was performed once a day, and mechanical hyperalgesia and edema were evaluated 0.5 hour after HISE for seven consecutive days. To investigate the role of the eCB system on the antihyperalgesic effect of HISE, non-exercised and exercised mice received intraperitoneal (ip), intrathecal (i.t.) or i.pl. injections of vehicle, AM281 (a CB
Substances chimiques
Cannabinoid Receptor Antagonists
0
Endocannabinoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1369-1378Subventions
Organisme : National Council for Scientific and Technological Development (CNPq)
ID : 430556/2018-7
Organisme : National Council for Scientific and Technological Development (CNPq)
ID : 309407/2017-6
Organisme : Foundation of Support for Research and Innovation of the State of Santa Catarina (FAPESC)
ID : 2019TR73
Organisme : Coordination for the Higher Education (CAPES)
Organisme : Unisul Scientific Initiation Program (PUIC), Brazil
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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