In vitro-in vivo evaluation of tetrahydrozoline-loaded ocular in situ gels on rabbits for allergic conjunctivitis management.
eye irritation
in situ gel
rabbit
tetrahydrozoline
topical drug delivery
Journal
Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
02
02
2020
revised:
15
04
2020
accepted:
17
04
2020
pubmed:
3
5
2020
medline:
2
9
2021
entrez:
3
5
2020
Statut:
ppublish
Résumé
Ocular allergy is one of the most common disorders of the eye surface. The conventional eye drops lack of therapeutic efficacy due to low ocular bioavailability and decreased drug residence time on eye surface. Hence, the present research work aimed to formulate, optimize, and evaluate the in situ gel for ophthalmic drug delivery. The prepared in situ gel formulations were evaluated for clarity, pH, gelling capacity, viscosity, osmolality, in vitro release study, and kinetic evaluation. ex vivo corneal permeation/penetration study using goat and in vivo studies on rabbits were also performed. Fourier-transformed infrared spectroscopy was also applied to study possible interactions between drug and polymers. The formulations found to be stable, nonirritant, and showed sustained release of the drug for a period of up to 24 hr with no ocular damage. The developed in situ gels loaded with tetrahydrozoline are alternative and promising ocular candidates for the treatment of allergic conjunctivitis.
Substances chimiques
Adrenergic Agonists
0
Gels
0
Imidazoles
0
Nasal Decongestants
0
tetrahydrozoline
S9U025Y077
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
716-727Informations de copyright
© 2020 Wiley Periodicals, Inc.
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