Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia.

Animals Australia Gammaretrovirus Phascolarctidae / virology Retroviridae Infections / veterinary South Australia Tumor Virus Infections / veterinary
Chlamydia koala koala retrovirus neoplasia

Journal

Journal of comparative pathology
ISSN: 1532-3129
Titre abrégé: J Comp Pathol
Pays: England
ID NLM: 0102444

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 24 10 2019
revised: 29 01 2020
accepted: 06 02 2020
entrez: 4 5 2020
pubmed: 4 5 2020
medline: 2 2 2021
Statut: ppublish

Résumé

Koala retrovirus (KoRV) infection shows differences in prevalence and load between northern and southern Australian koala populations; however, the effect of this on diseases such as lymphoma and chlamydial disease is unclear. This study compared clinicopathological findings, haematology and splenic lymphoid area of KoRV-positive koalas from northern (Queensland [Qld], n = 67) and southern (South Australia [SA], n = 92) populations in order to provide further insight into KoRV pathogenesis. Blood was collected for routine haematology and for measurement of KoRV proviral load by quantitative polymerase chain reaction (qPCR). Plasma samples were assessed for KoRV viral load by reverse transcriptase qPCR and conjunctival and cloacal swabs were collected for measurement of the load of Chlamydia pecorum (qPCR). During necropsy examination, spleen was collected for lymphoid area analysis. Lymphoma was morphologically similar between the populations and occurred in koalas with the highest KoRV proviral and viral loads. Severe ocular chlamydial disease was observed in both populations, but urinary tract disease was more severe in Qld, despite similar C. pecorum loads. No associations between KoRV and chlamydial disease severity or load were observed, except in SA where viral load correlated positively with chlamydial disease severity. In both populations, proviral and viral loads correlated positively with lymphocyte and metarubricyte counts and correlated negatively with erythrocyte and neutrophil counts. Splenic lymphoid area was correlated positively with viral load. This study has shown further evidence for KoRV-induced oncogenesis and highlighted that lymphocytes and splenic lymphoid tissue may be key sites for KoRV replication. However, KoRV infection appears to be highly complex and continued investigation is required to fully understand its pathogenesis.

Identifiants

DOI: 10.1016/j.jcpa.2020.02.003 PMID: 32359636
pubmed: 32359636
pii: S0021-9975(20)30018-9
doi: 10.1016/j.jcpa.2020.02.003
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

50-66

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

J Fabijan (J)

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia. Electronic address: jessica.fabijan@adelaide.edu.au.

N Sarker (N)

School of Veterinary Sciences, The University of Queensland, Gatton, Queensland, Australia.

N Speight (N)

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.

H Owen (H)

School of Veterinary Sciences, The University of Queensland, Gatton, Queensland, Australia.

J Meers (J)

School of Veterinary Sciences, The University of Queensland, Gatton, Queensland, Australia.

G Simmons (G)

School of Veterinary Sciences, The University of Queensland, Gatton, Queensland, Australia.

J Seddon (J)

School of Veterinary Sciences, The University of Queensland, Gatton, Queensland, Australia.

R D Emes (RD)

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire, UK.

R Tarlinton (R)

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire, UK.

F Hemmatzadeh (F)

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.

L Woolford (L)

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.

D J Trott (DJ)

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pathological Findings in Koala...
questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Australie › Pathological Findings in Koala...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Gammaretrovirus › Pathological Findings in Koala...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Marsupialia › Phascolarctidae › Pathological Findings in Koala...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Retroviridae › Pathological Findings in Koala...
questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Australie › Australie-Méridionale › Pathological Findings in Koala...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus oncogènes › Pathological Findings in Koala...