Retinoid metabolism and functions mediated by retinoid binding-proteins.
Binding-proteins
Cytochrome P-450
Retinal dehydrogenases
Retinal reductases
Retinoic acid
Retinol
Retinol dehydrogenases
Journal
Methods in enzymology
ISSN: 1557-7988
Titre abrégé: Methods Enzymol
Pays: United States
ID NLM: 0212271
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
4
5
2020
pubmed:
4
5
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
Cellular retinoid-binding proteins (BP) chaperone retinol through esterification, conversion of retinol into retinal, reduction of retinal, conversion of retinal into all-trans-retinoic acid (ATRA), and ATRA to catabolism. They also deliver ATRA to nuclear receptors and mediate non-genomic ATRA actions. These retinoid-specific binding-proteins include: cellular retinol binding-protein, type 1 (Crbp1), cellular retinol binding-protein type 2 (Crbp2), cellular retinol binding-protein type 3 (Crbp3), cellular retinoic acid binding-protein type 1 (Crabp1); cellular retinoic acid binding-protein type 2 (Crabp2). Retinoid BP bind their ligands specifically and with high-affinity. These BP seemingly evolved to solubilize the lipophilic retinoids in the aqueous cellular medium, and allow retinoid access only to enzymes that recognize both the BP and the retinoid. By chaperoning retinoids through cells, retinoid BP provide specificity to retinoids' metabolism and protect the scarce resource from dispersing into cell membranes and/or undergoing catabolism as xenobiotics. Other functions include non-genomic actions of Crabp1, delivery of ATRA to RAR by holo-Crabp2, and stabilization of HuR by apo-Crabp2. In addition to the retinoid-specific BP, Fabp5 also binds ATRA and delivers it to Pparδ. This article describes these BP and their functions, with a focus on experimental protocols to distinguish protein-protein interactions from diffusion-mediated transfer of ligand from BP to enzymes or receptors, and methods for quantifying retinoids.
Identifiants
pubmed: 32359659
pii: S0076-6879(20)30082-3
doi: 10.1016/bs.mie.2020.02.004
pmc: PMC7357351
mid: NIHMS1604307
pii:
doi:
Substances chimiques
Retinoids
0
Retinol-Binding Proteins
0
Retinol-Binding Proteins, Cellular
0
Vitamin A
11103-57-4
Tretinoin
5688UTC01R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-75Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK102014
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112754
Pays : United States
Informations de copyright
© 2020 Elsevier Inc. All rights reserved.
Références
Mol Pharmacol. 2015;87(3):430-41
pubmed: 25492813
Subcell Biochem. 2016;81:179-199
pubmed: 27830505
Proteins. 1990;8(1):44-61
pubmed: 2217163
Biochim Biophys Acta. 1997 Oct 17;1342(2):175-81
pubmed: 9392526
J Biol Chem. 1999 Aug 20;274(34):23695-8
pubmed: 10446126
FEBS Lett. 2016 Aug;590(16):2527-35
pubmed: 27416800
Biochemistry. 1992 Jul 28;31(29):6748-55
pubmed: 1322170
Mol Cell Biol. 2012 Aug;32(15):3164-75
pubmed: 22665496
J Biol Chem. 1988 Nov 25;263(33):17715-23
pubmed: 3053716
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3483-7
pubmed: 4519641
J Biol Chem. 1978 Jul 10;253(13):4551-4
pubmed: 566269
J Biol Chem. 1978 Feb 10;253(3):828-32
pubmed: 563865
Biochem Pharmacol. 2012 Jan 1;83(1):149-63
pubmed: 22020119
J Biol Chem. 1988 Sep 15;263(26):12916-9
pubmed: 3417642
Annu Rev Nutr. 2011 Aug 21;31:65-87
pubmed: 21529158
Mol Cell. 2005 Apr 29;18(3):343-53
pubmed: 15866176
J Endocrinol. 2018 Mar;236(3):151-165
pubmed: 29371236
Anal Biochem. 2015 Sep 1;484:162-8
pubmed: 26045160
J Lipid Res. 1985 Mar;26(3):387-92
pubmed: 3989394
PLoS One. 2014 Jun 09;9(6):e99435
pubmed: 24911926
Dev Dyn. 2005 May;233(1):167-76
pubmed: 15765518
J Biol Chem. 1988 Apr 25;263(12):5789-96
pubmed: 3281946
J Biol Chem. 2002 Sep 27;277(39):36617-23
pubmed: 12138113
Subcell Biochem. 2016;81:21-76
pubmed: 27830500
Anal Biochem. 2008 Jul 1;378(1):71-9
pubmed: 18410739
J Mol Biol. 2006 Oct 27;363(3):687-701
pubmed: 16979656
Biochemistry. 1991 Jun 25;30(25):6224-30
pubmed: 2059629
Pharmacol Ther. 2017 May;173:19-33
pubmed: 28132904
Anal Chem. 2008 Mar 1;80(5):1702-8
pubmed: 18251521
Methods Mol Biol. 1998;89:105-10
pubmed: 9664322
Biochemistry. 2003 Apr 15;42(14):4190-6
pubmed: 12680773
Development. 1995 Feb;121(2):539-48
pubmed: 7768191
Biochim Biophys Acta. 2012 Jan;1821(1):70-7
pubmed: 21718801
J Biol Chem. 2011 Dec 9;286(49):42749-57
pubmed: 21998312
J Biol Chem. 1992 Sep 25;267(27):19676-82
pubmed: 1527087
J Biol Chem. 2015 Mar 13;290(11):7259-68
pubmed: 25627686
Int J Mol Sci. 2019 Jul 24;20(15):
pubmed: 31344789
Mol Cell Biol. 2011 Aug;31(16):3277-85
pubmed: 21670153
J Biol Chem. 1996 Jul 5;271(27):16288-93
pubmed: 8663198
Methods Mol Biol. 2010;652:1-54
pubmed: 20552420
Biochem J. 2005 May 15;388(Pt 1):363-9
pubmed: 15628969
J Biol Chem. 1987 Feb 25;262(6):2729-36
pubmed: 3818619
Mol Cell Biol. 2014 Jun;34(12):2135-46
pubmed: 24687854
J Biol Chem. 1991 Sep 5;266(25):16572-9
pubmed: 1653241
J Biol Chem. 1984 Feb 10;259(3):1476-82
pubmed: 6537950
J Biol Chem. 1991 Nov 25;266(33):22273-8
pubmed: 1939249
Biochem Biophys Res Commun. 1988 Oct 14;156(1):157-63
pubmed: 3178828
J Struct Biol. 2017 Mar;197(3):330-339
pubmed: 28057518