Short duration of post-amputation antibiotic therapy in diabetic foot patients with total resection of osteomyelitis.
Aged
Amputation, Surgical
/ adverse effects
Anti-Bacterial Agents
/ administration & dosage
Combined Modality Therapy
Debridement
/ adverse effects
Diabetic Foot
/ complications
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Male
Middle Aged
Osteomyelitis
/ complications
Postoperative Care
/ methods
Postoperative Period
Recurrence
Surgical Wound Infection
/ prevention & control
Time Factors
Treatment Outcome
Antibiotic duration
Diabetes
Diabetic foot osteomyelitis
Osteomyelitis
Journal
Medecine et maladies infectieuses
ISSN: 1769-6690
Titre abrégé: Med Mal Infect
Pays: France
ID NLM: 0311416
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
25
11
2019
revised:
07
01
2020
accepted:
17
04
2020
pubmed:
4
5
2020
medline:
29
6
2021
entrez:
4
5
2020
Statut:
ppublish
Résumé
Short duration of post-amputation antibiotic therapy (2-5 days) is recommended in patients with diabetic foot osteomyelitis after total resection of infected bone tissue. To evaluate the long-term effectiveness of short-duration post-amputation antibiotic therapy in diabetic patients with total resection of osteomyelitis assessed by sterile bone bacteriological samples obtained from the resection margin. The endpoint was the absence of osteomyelitis relapse at 6 months, defined as recurrence of osteomyelitis with the need for surgical revision and/or new bone antibiotic therapy. Among 15 patients included, 12 (80%) were cured without recurrence of osteomyelitis at 6 months, with a mean duration of antibiotic therapy of 8.3±5.9 days post surgery. This result is comparable to literature data, while all of them reported longer duration of antibiotic therapy and/or shorter follow-up. Short duration of post-amputation antibiotic therapy in diabetic patients with sterile bacteriological samples obtained from resection margin seems effective.
Sections du résumé
BACKGROUND
BACKGROUND
Short duration of post-amputation antibiotic therapy (2-5 days) is recommended in patients with diabetic foot osteomyelitis after total resection of infected bone tissue.
OBJECTIVE
OBJECTIVE
To evaluate the long-term effectiveness of short-duration post-amputation antibiotic therapy in diabetic patients with total resection of osteomyelitis assessed by sterile bone bacteriological samples obtained from the resection margin.
METHODS
METHODS
The endpoint was the absence of osteomyelitis relapse at 6 months, defined as recurrence of osteomyelitis with the need for surgical revision and/or new bone antibiotic therapy.
RESULTS
RESULTS
Among 15 patients included, 12 (80%) were cured without recurrence of osteomyelitis at 6 months, with a mean duration of antibiotic therapy of 8.3±5.9 days post surgery. This result is comparable to literature data, while all of them reported longer duration of antibiotic therapy and/or shorter follow-up.
CONCLUSION
CONCLUSIONS
Short duration of post-amputation antibiotic therapy in diabetic patients with sterile bacteriological samples obtained from resection margin seems effective.
Identifiants
pubmed: 32360115
pii: S0399-077X(20)30119-0
doi: 10.1016/j.medmal.2020.04.015
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
433-435Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.