Caffeic acid oligomers from Mesona chinensis and their In Vitro antiviral activities.

Antiviral Agents / isolation & purification Caffeic Acids / isolation & purification Cell Line, Tumor China Humans Lamiaceae / chemistry Molecular Structure Phytochemicals / isolation & purification Plant Components, Aerial / chemistry Respiratory Syncytial Virus, Human / drug effects
Anti-RSV activity Caffeic acid oligomer Mesona chinensis

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 14 03 2020
revised: 18 04 2020
accepted: 18 04 2020
pubmed: 4 5 2020
medline: 10 2 2021
entrez: 4 5 2020
Statut: ppublish

Résumé

The phytochemical study of the aerial part of Mesona chinensis led to the isolation of five new caffeic acid oligomers (1-5), as well as four known analogues (6-9). The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, chemical method, and quantum-chemical electronic circular dichroism (ECD) calculation. Among the isolates, compound 7 showed significant in vitro antiviral activity on respiratory syncytial virus (RSV).

Identifiants

DOI: 10.1016/j.fitote.2020.104603 PMID: 32360288
pubmed: 32360288
pii: S0367-326X(20)30185-4
doi: 10.1016/j.fitote.2020.104603
pii:
doi:

Substances chimiques

Antiviral Agents 0
Caffeic Acids 0
Phytochemicals 0
caffeic acid U2S3A33KVM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104603

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no conflicts of interest.

Auteurs

Zi-Qin Wang (ZQ)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.

Qiao-Yun Song (QY)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.

Jun-Cheng Su (JC)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.

Wei Tang (W)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.

Jian-Guo Song (JG)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.

Xiao-Jun Huang (XJ)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.

Jinmeng An (J)

Guangzhou Wanglaoji Great Health Industry Co., Ltd., Guangzhou 510623, People's Republic of China.

Yao-Lan Li (YL)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.

Wen-Cai Ye (WC)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: chywc@aliyun.com.

Ying Wang (Y)

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: wangying_cpu@163.com.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Cinnamates › Acides caféiques › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Lamiaceae › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Caffeic acid oligomers from Mesona chinensis...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Paramyxoviridae › Pneumovirinae › Pneumovirus › Virus respiratoires syncytiaux › Virus respiratoire syncytial humain › Caffeic acid oligomers from Mesona chinensis...