Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease.

Adipose Tissue, Beige / metabolism Adipose Tissue, Brown / metabolism Animals Calorimetry Diet, High-Fat / adverse effects Discoidin Domain Receptor 1 / genetics Disease Models, Animal Disease Susceptibility Energy Metabolism Fibrosis Gene Deletion Immunohistochemistry Metabolic Syndrome / diagnosis Mice Mice, Knockout Positron-Emission Tomography RNA, Messenger / genetics Subcutaneous Fat / metabolism Tomography, X-Ray Computed
Collagen Diabetes Discoidin domain receptor 1 Fibrosis Obesity brown fat

Journal

Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730

Informations de publication

Date de publication:
09 2020
Historique:
received: 04 02 2020
revised: 10 04 2020
accepted: 20 04 2020
pubmed: 4 5 2020
medline: 9 7 2021
entrez: 4 5 2020
Statut: ppublish

Résumé

Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and calcification in the vascular system in cardiometabolic disease. This spectrum of activity led us to question whether DDR1 might also regulate adipose tissue fibrosis and remodeling. We have used a diet-induced mouse model of cardiometabolic disease to determine whether DDR1 deletion impacts upon adipose tissue remodeling and metabolic dysfunction. Mice were fed a high fat diet (HFD) for 12 weeks, followed by assessment of glucose and insulin tolerance, respiration via indirect calorimetry, and brown fat activity by FDG-PET. Feeding HFD induced DDR1 expression in white adipose tissue, which correlated with adipose tissue expansion and fibrosis. Ddr1 This study is the first to identify a role for DDR1 as a driver of adipose tissue fibrosis and suppressor of beneficial beige fat formation.

Identifiants

DOI: 10.1016/j.molmet.2020.101006 PMID: 32360427 PMC: PMC7242876
pubmed: 32360427
pii: S2212-8778(20)30080-6
doi: 10.1016/j.molmet.2020.101006
pmc: PMC7242876
pii:
doi:

Substances chimiques

RNA, Messenger 0
Ddr1 protein, mouse EC 2.7.10.1
Discoidin Domain Receptor 1 EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101006

Subventions

Organisme : CIHR
ID : MOP133592
Pays : Canada

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier GmbH.. All rights reserved.

Références

Circ Res. 2008 May 23;102(10):1202-11
pubmed: 18451340
Cell Metab. 2018 Jan 9;27(1):180-194.e6
pubmed: 29320702
Nat Commun. 2017 Feb 06;8:14360
pubmed: 28165007
Mol Cell. 1997 Dec;1(1):13-23
pubmed: 9659899
Diabetes Res Clin Pract. 2011 Dec;94(3):311-21
pubmed: 22079683
Mol Cell Biol. 2001 Apr;21(8):2906-17
pubmed: 11283268
Pharmacol Rep. 2019 Aug;71(4):721-731
pubmed: 31207434
Cell Signal. 2006 Aug;18(8):1108-16
pubmed: 16626936
Circ Res. 2010 Jun 11;106(11):1775-83
pubmed: 20448217
Cell Rep. 2017 Feb 14;18(7):1774-1790
pubmed: 28199848
Circ Res. 2009 Nov 20;105(11):1141-8
pubmed: 19834008
Science. 2005 Aug 12;309(5737):1074-8
pubmed: 16099986
Oncotarget. 2016 Jul 19;7(29):44975-44990
pubmed: 27391444
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2589-96
pubmed: 17932314
Nature. 2008 Aug 21;454(7207):1000-4
pubmed: 18719589
Cell Adh Migr. 2018;12(4):348-362
pubmed: 29513135
Stud Health Technol Inform. 2002;85:586-92
pubmed: 15458157
Cell Metab. 2007 Jul;6(1):38-54
pubmed: 17618855
Cell. 1998 Mar 20;92(6):829-39
pubmed: 9529258
Genes Dev. 2008 May 15;22(10):1397-409
pubmed: 18483224
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
Am J Respir Crit Care Med. 2006 Aug 15;174(4):420-7
pubmed: 16690978
Diabetologia. 2012 Jan;55(1):154-65
pubmed: 21947380
J Clin Invest. 2001 Mar;107(6):727-35
pubmed: 11254672
Cell Metab. 2013 Oct 1;18(4):470-7
pubmed: 23954640
Circ Res. 2002 Jun 14;90(11):1147-9
pubmed: 12065315
Am J Pathol. 2011 Jul;179(1):83-91
pubmed: 21640971
J Mol Biol. 2014 Jun 26;426(13):2457-70
pubmed: 24768818
Mol Cell. 1999 Oct;4(4):611-7
pubmed: 10549292
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1878-1889
pubmed: 29930002
Cell Rep. 2018 May 15;23(7):1977-1987
pubmed: 29768198
Nat Commun. 2014 Mar 19;5:3485
pubmed: 24647224
Mol Cell Biol. 2009 Mar;29(6):1575-91
pubmed: 19114551
N Engl J Med. 2009 Apr 9;360(15):1509-17
pubmed: 19357406
Cell. 2015 Jan 15;160(1-2):105-18
pubmed: 25579684
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965
Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G1043-52
pubmed: 22345552
Matrix Biol. 2010 Jun;29(5):346-56
pubmed: 20307660
Lancet. 2017 Dec 16;390(10113):2627-2642
pubmed: 29029897
J Clin Invest. 2017 Jan 3;127(1):74-82
pubmed: 28045400
Cell. 2014 Jan 16;156(1-2):20-44
pubmed: 24439368

Auteurs

Marsel Lino (M)

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada.

David Ngai (D)

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada.

Alison Liu (A)

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada.

Amanda Mohabeer (A)

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada.

Cameron Harper (C)

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada.

Laura-Lee Caruso (LL)

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada.

Stephanie A Schroer (SA)

Toronto General Hospital Research Institute, Department of Medicine, University of Toronto, 101 College Street, Toronto, ON, Canada.

Fred Fu (F)

STTARR Innovation Center, University Health Network, 101 College Street, Toronto, ON, Canada.

Trevor McKee (T)

STTARR Innovation Center, University Health Network, 101 College Street, Toronto, ON, Canada.

Adria Giacca (A)

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada.

Minna Woo (M)

Toronto General Hospital Research Institute, Department of Medicine, University of Toronto, 101 College Street, Toronto, ON, Canada.

Michelle P Bendeck (MP)

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada. Electronic address: michelle.bendeck@utoronto.ca.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux beige › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux brun › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Eucaryotes › Animaux › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Calorimétrie › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteur mitogène › Récepteurs à domaine discoïdine › Récepteur-1 à domaine discoïdine › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndrome métabolique X › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Graisse sous-cutanée › Discoidin domain receptor 1-deletion...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Discoidin domain receptor 1-deletion...