The role of epithelial-mesenchymal transition in regulating radioresistance.
EMT
Mechanism
Non-coding RNAs
Radioresistance
Signaling pathway
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
30
10
2019
revised:
06
04
2020
accepted:
08
04
2020
pubmed:
4
5
2020
medline:
17
6
2020
entrez:
4
5
2020
Statut:
ppublish
Résumé
Cancer patients with different stages can benefit from radiotherapy, but there are still limited due to inherent or acquired radioresistance. The epithelial-mesenchymal transition (EMT) is a complex biological process that is implicated in malignant characteristics of cancer, such as radioresistance. Although the possible mechanisms of EMT-dependent radioresistance are being extensively studied, there is a lack of a clear picture of the overall signaling of EMT-mediated radioresistance. In this review, we highlight the role and possible molecular mechanisms of EMT in cancer radioresistance, in particular to EMT-associated signaling pathway, EMT-inducing transcription factors (EMT-TFs), EMT-related non-coding RNAs. The knowledge of EMT-associated mechanisms of radioresistance will offer more potent therapy targets to improve the radiotherapy responses.
Identifiants
pubmed: 32361589
pii: S1040-8428(20)30099-8
doi: 10.1016/j.critrevonc.2020.102961
pii:
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102961Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.