The CD83 Molecule - An Important Immune Checkpoint.
Adaptive Immunity
Animals
Antigens, CD
/ chemistry
Autoimmunity
B-Lymphocytes
/ immunology
Cell Differentiation
/ immunology
Dendritic Cells
/ immunology
Host Microbial Interactions
/ immunology
Humans
Immune Checkpoint Proteins
/ chemistry
Immune Tolerance
Immunoglobulins
/ chemistry
Membrane Glycoproteins
/ chemistry
Mice
T-Lymphocytes, Regulatory
/ immunology
CD83 Antigen
CD83
Treg cells
autoimmunity
immune tolerance
viral escape mechanism
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
02
2020
accepted:
30
03
2020
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
1
4
2021
Statut:
epublish
Résumé
The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed that CD83 is not a typical co-stimulatory molecule, but rather plays a critical role in controlling and resolving immune responses. Moreover, CD83 is an essential factor during the differentiation of T and B lymphocytes, and the development and maintenance of tolerance. The identification of its interaction partners as well as signaling pathways have been an enigma for the last decades. Here, we report the latest data on the expression, structure, and the signaling partners of CD83. In addition, we review the regulatory functions of CD83, including its striking modulatory potential to maintain the balance between tolerance versus inflammation during homeostasis or pathologies. These immunomodulatory properties of CD83 emphasize its exceptional therapeutic potential, which has been documented in specific preclinical disease models.
Identifiants
pubmed: 32362900
doi: 10.3389/fimmu.2020.00721
pmc: PMC7181454
doi:
Substances chimiques
Antigens, CD
0
Immune Checkpoint Proteins
0
Immunoglobulins
0
Membrane Glycoproteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
721Informations de copyright
Copyright © 2020 Grosche, Knippertz, König, Royzman, Wild, Zinser, Sticht, Muller, Steinkasserer and Lechmann.
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