Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma.
Immunotherapy
T cell
bladder cancer
checkpoint inhibitor
macrophage
Journal
Oncoimmunology
ISSN: 2162-4011
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
08
2019
revised:
04
11
2019
accepted:
09
12
2019
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
5
5
2020
Statut:
epublish
Résumé
Patients with locally advanced and metastatic urothelial carcinoma have a low survival rate (median 15.7 months, 13.1-17.8), with only a 23% response rate to monotherapy treatment with anti-PDL1 checkpoint immunotherapy. To identify new therapeutic targets, we profiled the immune regulatory signatures during murine cancer development using the BBN carcinogen and identified an increase in the expression of the T cell inhibitory protein B7-H4 (VTCN1, B7S1, B7X). B7-H4 expression temporally correlated with decreased lymphocyte infiltration. While the increase in B7-H4 expression within the bladder by CD11b
Identifiants
pubmed: 32363111
doi: 10.1080/2162402X.2020.1744897
pii: 1744897
pmc: PMC7185218
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
1744897Subventions
Organisme : BLRD VA
ID : I01 BX003692
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180944
Pays : United States
Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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