Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy.
Animals
Antineoplastic Agents
/ chemical synthesis
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Drug Delivery Systems
Drug Screening Assays, Antitumor
Halogenation
Hep G2 Cells
Humans
Liposomes
/ chemistry
Liver Neoplasms, Experimental
/ drug therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Molecular Structure
Optical Imaging
Particle Size
Photochemotherapy
Porphyrins
/ chemical synthesis
Surface Properties
Surface-Active Agents
/ chemical synthesis
Theranostic Nanomedicine
Journal
Journal of materials chemistry. B
ISSN: 2050-7518
Titre abrégé: J Mater Chem B
Pays: England
ID NLM: 101598493
Informations de publication
Date de publication:
27 05 2020
27 05 2020
Historique:
pubmed:
5
5
2020
medline:
13
4
2021
entrez:
5
5
2020
Statut:
ppublish
Résumé
Convenient strategies to transform regular liposomes or nano-micelles into multifunctional theranostics would be highly valuable in cancer therapy. Herein, we developed an amphiphilic fluorinated porphyrin dendrimer as a multifunctional "add-on" module which would self-assemble onto liposomal drug delivery systems and conveniently transform the liposomes into novel theranostics. Through cancer cells and murine xenograft tumor model assays, the theranostics showed valuable fluorescence/19F magnetic resonance dual modal imaging and highly efficient chemo-photodynamic therapy. The modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics.
Substances chimiques
Antineoplastic Agents
0
Liposomes
0
Porphyrins
0
Surface-Active Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM