Indwelling catheterization, renal stones, and hydronephrosis are risk factors for symptomatic Staphylococcus aureus-related urinary tract infection.
Adolescent
Adult
Aged
Aged, 80 and over
Catheter-Related Infections
/ diagnosis
Catheters, Indwelling
/ adverse effects
Child
Child, Preschool
Female
Humans
Hydronephrosis
/ complications
Infant
Kidney Calculi
/ complications
Male
Middle Aged
Retrospective Studies
Risk Factors
Staphylococcal Infections
/ diagnosis
Staphylococcus aureus
Urinary Tract Infections
/ diagnosis
Young Adult
Hydronephrosis
Indwelling catheter
Renal stones
Staphylococcus aureus
Urinary tract infection
Journal
World journal of urology
ISSN: 1433-8726
Titre abrégé: World J Urol
Pays: Germany
ID NLM: 8307716
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
24
12
2019
accepted:
24
04
2020
pubmed:
5
5
2020
medline:
23
7
2021
entrez:
5
5
2020
Statut:
ppublish
Résumé
Staphylococcus aureus is a relatively uncommon causative agent of urinary tract infection (UTI). However, the clinical features of S. aureus-related UTI are unclear. Thus, we aimed to clarify how patients with S. aureus bacteriuria develop UTI and determine the features and clinical risk factors of symptomatic S. aureus-related UTI. We performed a retrospective study of patients at the Hiroshima University Hospital for whom S. aureus had been isolated from urine culture from January 2010 to December 2017. The characteristics (age, sex, body mass index, indwelling catheterization, renal stones, hydronephrosis, anticancer drug use, diabetes mellitus, steroid use, serum albumin, antibiotic use in the past 1 month, estimated glomerular filtration rate, benign prostate hyperplasia, and neurogenic bladder) of patients with UTI and those without UTI were compared, and the risk factors for S. aureus-related UTI were identified by multiple logistic regression model. A total of 286 patients with S. aureus bacteriuria were analyzed; 33 patients developed UTI. The causative pathogens were methicillin-sensitive S. aureus and methicillin-resistant S. aureus (MRSA) in 14 and 19 patients, respectively, who developed UTI. This study demonstrated that indwelling catheterization, hydronephrosis, and renal stones are significantly associated with S. aureus-related UTI (p = 0.01, odds ratio = 3.1; and p < 0.01, odds ratio = 7.0; and p = 0.02, odds ratio = 1.2; respectively) and hypoalbuminemia in MRSA-related UTI (p < 0.01). Paying attention to risk factors, specifically indwelling catheterization, renal stones, and hydronephrosis, will be an effective strategy for prevention of S. aureus-related UTI with persistent staphylococcal bacteriuria.
Identifiants
pubmed: 32363449
doi: 10.1007/s00345-020-03223-x
pii: 10.1007/s00345-020-03223-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
511-516Références
Karakonstantis S, Kalemaki D (2018) The clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteremia. A review and meta-analysis. Infect Dis (Lond) 50:648–659. https://doi.org/10.1080/23744235.2018.1445280
doi: 10.1080/23744235.2018.1445280
Holland TL, Fowler VG Jr, Lowy FD, Baron EL (2017) Clinical manifestation of Staphylococcus aureus infection in adults. Up-to-date. https://www.uptodate.com/contents/clinical-manifestations-of-staphylococcus-aureus-infection-in-adults
Ekkelenkamp MB, Verhoef J, Bonten MJ (2007) Quantifying the relationship between Staphylococcus aureus bacteremia and S. aureus bacteriuria: a retrospective analysis in a tertiary care hospital. Clin Infect Dis 44:1457–1459. https://doi.org/10.1086/517505
doi: 10.1086/517505
pubmed: 17479942
Barrett SP, Savage MA, Rebec MP, Guyot A, Andrews N, Shrimpton SB (1999) Antibiotic sensitivity of bacteria associated with community-acquired urinary tract infection in Britain. J Antimicrob Chemother 44:359–365. https://doi.org/10.1093/jac/44.3.359
doi: 10.1093/jac/44.3.359
pubmed: 10511403
Goldstein FW (2000) Antibiotic susceptibility of bacterial strains isolated from patients with community-acquired urinary tract infections in France. Multicentre Study Group. Eur J Clin Microbiol Infect Dis 19:112–117. https://doi.org/10.1007/s100960050440
doi: 10.1007/s100960050440
pubmed: 10746497
Muder RR, Brennen C, Rihs JD, Wagener MM, Obman A, Stout JE, Yu VL (2006) Isolation of Staphylococcus aureus from the urinary tract: association of isolation with symptomatic urinary tract infection and subsequent Staphylococcal bacteremia. Clin Infect Dis 42:46–50. https://doi.org/10.1086/498518
doi: 10.1086/498518
pubmed: 16323090
Demuth PJ, Gerding DN, Crossley K (1979) Staphylococcus aureus bacteriuria. Arch Intern Med 139:78–80
doi: 10.1001/archinte.1979.03630380056019
Baraboutis IG, Tsagalou EP, Lepinski JL, Papakonstantinou I, Papastamopoulos V, Skoutelis AT, Johnson S (2010) Primary Staphylococcus aureus urinary tract infection: the role of undetected hematogenous seeding of the urinary tract. Eur J Clin Microbiol Infect Dis 29:1095–1101. https://doi.org/10.1007/s10096-010-0967-2
doi: 10.1007/s10096-010-0967-2
pubmed: 20703891
Shupp Byrne DE, Sedor JF, Soroush M, McCue PA, Mulholland SG (2001) Interaction of bladder glycoprotein GP51 with uropathogenic bacteria. J Urol 165:1342–1346. https://doi.org/10.1097/00005392-200104000-00081
doi: 10.1097/00005392-200104000-00081
pubmed: 11257713
Grabe M, Bartoletti R, Johansen TEB et al (2015) Guidelines on urologic infections. Eur Urology 1–86
Shoeb HA, Tawfik AF, Shibl AM (1991) A nitrate reductase-based colorimetric assay for the study of bacterial adherence. J Appl Bacteriol 71:270–276. https://doi.org/10.1111/j.1365-2672.1991.tb04458.x
doi: 10.1111/j.1365-2672.1991.tb04458.x
pubmed: 1955419
Arpi M, Renneberg J (1984) The clinical significance of Staphylococcus aureus bacteriuria. J Urol 132:697–700. https://doi.org/10.1016/s0022-5347(17)49833-8
doi: 10.1016/s0022-5347(17)49833-8
pubmed: 6471216
Saidel-Odes L, Riesenberg K, Schlaeffer F, Borer A (2009) Epidemiological and clinical characteristics of methicillin sensitive Staphylococcus aureus (MSSA) bacteriuria. J Infect 58:119–122. https://doi.org/10.1016/j.jinf.2008.11.014
doi: 10.1016/j.jinf.2008.11.014
pubmed: 19144410
Walton-Diaz A, Vinay JI, Barahona J et al (2017) Concordance of renal stone culture: PMUC, RPUC, RSC and post-PCNL sepsis-a non-randomized prospective observation cohort study. Int Urol Nephrol 49:31–35. https://doi.org/10.1007/s11255-016-1457-y
doi: 10.1007/s11255-016-1457-y
pubmed: 27848063
Ribera MC, Pascual R, Orozco D, Pérez Barba C, Pedrera V, Gil V (2006) Incidence and risk factors associated with urinary tract infection in diabetic patients with and without asymptomatic bacteriuria. Eur J Clin Microbiol Infect Dis 25:389–393. https://doi.org/10.1007/s10096-006-0148-5
doi: 10.1007/s10096-006-0148-5
pubmed: 16767487
Semins MJ, Shore AD, Makary MA, Weiner J, Matlage BR (2012) The impact of obesity on urinary tract infection risk. Urology 79:266–269. https://doi.org/10.1016/j.urology.2011.09.040
doi: 10.1016/j.urology.2011.09.040
pubmed: 22130358
Jepsen OB, Larsen SO, Dankert J et al (1982) Urinary-tract infection and bacteremia in hospitalized medical patients—a European multicenter prevalence survey on nosocomial infection. J Hosp Infect 3:241–252. https://doi.org/10.1016/0195-6701(82)90043-3
doi: 10.1016/0195-6701(82)90043-3
pubmed: 6183317
Reller B, Murdoch D. Incidence of concomitant bacteremia in patients with Staphylococcus aureus bacteriuria. IDSA42
Stokes W, Parkins MD, Parfitt ECT, Ruiz JC, Mugford G, Gregson DB (2019) Incidence and outcomes of Staphylococcus aureus bacteriuria: a population-based study. Clin Infect Dis 69:963–969. https://doi.org/10.1093/cid/ciy1000
doi: 10.1093/cid/ciy1000
pubmed: 30476003
Anon (1993) The spread of EMRSA-16. Commun Dis Rep CDR Wkly 27:121
Al Mohajer M, Darouiche RO (2012) Staphylococcus aureus bacteriuria: source, clinical relevance, and management. Curr Infect Dis Rep 14:601–606. https://doi.org/10.1007/s11908-012-0290-4
doi: 10.1007/s11908-012-0290-4
pubmed: 22945379
Araki M, Kariyama R, Monden K, Tsugawa M, Kumon H (2002) Molecular epidemiological studies of Staphylococcus aureus in urinary tract infection. J Infect Chemother 8:168–174. https://doi.org/10.1007/s101560200029
doi: 10.1007/s101560200029
pubmed: 12111571
Jones JW, Carter A, Ewings P, O’Boyle PJ (1999) An MRSA outbreak in a urology ward and its association with Nd: YAG coagulation laser treatment of the prostate. J Hosp Infect 41:39–44. https://doi.org/10.1016/S0195-6701(99)90035-X
doi: 10.1016/S0195-6701(99)90035-X
pubmed: 9949963
Coll PP, Crabtree BF, O’Connor PJ, Klenzak S (1994) Clinical risk factors for methicillin-resistant Staphylococcus aureus bacteriuria in a skilled-care nursing home. Arch Fam Med 3:357–360. https://doi.org/10.1001/archfami.3.4.357
doi: 10.1001/archfami.3.4.357
pubmed: 8012624