Bisphenol A exposure disrupts aspartate transport in HepG2 cells.
bisphenol A
gene expression regulation
liver SLC1 transporters
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
22
11
2019
revised:
17
03
2020
accepted:
22
04
2020
pubmed:
5
5
2020
medline:
28
4
2021
entrez:
5
5
2020
Statut:
ppublish
Résumé
The liver is the organ responsible for bisphenol A (BPA) metabolism, an environmental chemical agent. Exposure to this toxin is associated with liver abnormalities and dysfunction. An important role played by excitatory amino acid transporters (EAATs) of the slc1 gene family has been reported in liver injuries. To gain insight into a plausible effect of BPA exposure in the liver glutamate/aspartate transport, using the human hepatoblastoma cell line HepG2, we report a BPA-dependent dynamic regulation of SLC1A3 and SLC1A2. Through the use of radioactive [
Substances chimiques
Benzhydryl Compounds
0
Excitatory Amino Acid Transporter 1
0
Excitatory Amino Acid Transporter 2
0
Phenols
0
SLC1A2 protein, human
0
SLC1A3 protein, human
0
YY1 Transcription Factor
0
YY1 protein, human
0
Aspartic Acid
30KYC7MIAI
bisphenol A
MLT3645I99
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22516Subventions
Organisme : Consejo Nacional de Ciencia y Tecnología, Mexico
ID : 210238
Organisme : Consejo Nacional de Ciencia y Tecnología, Mexico
ID : 255087
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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