Pediococcus pentosaceus LI05 alleviates DSS-induced colitis by modulating immunological profiles, the gut microbiota and short-chain fatty acid levels in a mouse model.
Journal
Microbial biotechnology
ISSN: 1751-7915
Titre abrégé: Microb Biotechnol
Pays: United States
ID NLM: 101316335
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
14
01
2020
revised:
12
04
2020
accepted:
12
04
2020
pubmed:
5
5
2020
medline:
15
5
2021
entrez:
5
5
2020
Statut:
ppublish
Résumé
The gut microbiota is considered a key factor in pathogenesis and progression of inflammatory bowel disease (IBD). The bacterium Pediococcus pentosaceus LI05 alleviated host inflammation by maintaining the gut epithelial integrity, modulating the host immunity, gut microbiota and metabolism, but its effect on IBD remains unclear. The present study aimed to investigate the role and mechanisms of P. pentosaceus LI05. Mice were administered P. pentosaceus LI05 or phosphate-buffered saline once daily by oral gavage for 14 days, and colitis was induced by providing mice 2% DSS-containing drinking water for 7 days. P. pentosaceus LI05 ameliorated colitis in mice and reduced the body weight loss, disease activity index (DAI) scores, colon length shortening, intestinal permeability and the proinflammatory cytokine levels. Furthermore, a significantly altered gut microbiota composition with increased diversity and short-chain fatty acid (SCFA) production was observed in mice treated with P. pentosaceus LI05. Several genera, including Akkermansia and Faecalibacterium, were differentially enriched in the P. pentosaceus LI05-treated mice and were negatively correlated with colitis indices and positively correlated with gut barrier markers and SCFA levels. The P. pentosaceus LI05 treatment alleviated intestinal inflammation by maintaining the intestinal epithelial integrity and modulating the immunological profiles, gut microbiome and metabolite composition. Based on our findings, P. pentosaceus LI05 might be applied as potential preparation to ameliorate colitis.
Identifiants
pubmed: 32363766
doi: 10.1111/1751-7915.13583
pmc: PMC7264873
doi:
Substances chimiques
Fatty Acids, Volatile
0
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1228-1244Informations de copyright
© 2020 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.
Références
Benef Microbes. 2017 Apr 26;8(2):179-192
pubmed: 28008784
Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G338-46
pubmed: 24875104
Biochem Pharmacol. 2013 Mar 15;85(6):798-807
pubmed: 23261528
Gut. 2004 Jul;53(7):1057
pubmed: 15194668
Gut. 2008 Jun;57(6):764-71
pubmed: 18250125
Science. 2013 Aug 2;341(6145):569-73
pubmed: 23828891
PLoS One. 2012;7(1):e31131
pubmed: 22303484
Gastroenterology. 2018 Mar;154(4):1037-1046.e2
pubmed: 29174952
Gut. 2006 Feb;55(2):205-11
pubmed: 16188921
PLoS One. 2012;7(9):e46399
pubmed: 23029509
Toxicol Lett. 2016 Jan 22;241:103-10
pubmed: 26617183
Pharmacol Res. 2018 Feb;128:63-72
pubmed: 28827186
J Gastroenterol. 2003 Mar;38 Suppl 15:36-42
pubmed: 12698869
Front Microbiol. 2017 Sep 26;8:1804
pubmed: 29033903
Inflamm Bowel Dis. 2009 Aug;15(8):1183-9
pubmed: 19235886
Biochem Biophys Res Commun. 2013 Jul 26;437(2):267-73
pubmed: 23811270
Inflamm Bowel Dis. 2007 Jun;13(6):675-83
pubmed: 17262808
Front Microbiol. 2019 Oct 01;10:2259
pubmed: 31632373
Cent Eur J Immunol. 2015;40(4):442-6
pubmed: 26862308
Front Med (Lausanne). 2014 Aug 25;1:24
pubmed: 25593900
Scand J Gastroenterol. 2013 Oct;48(10):1136-44
pubmed: 23971882
Nature. 2013 Dec 19;504(7480):451-5
pubmed: 24226773
Acta Physiol (Oxf). 2016 Aug;217(4):300-10
pubmed: 27096537
Minerva Med. 2011 Aug;102(4):309-19
pubmed: 21959704
PLoS One. 2015 Apr 24;10(4):e0123013
pubmed: 25910186
J Crohns Colitis. 2013 Dec;7(11):e558-68
pubmed: 23643066
Aliment Pharmacol Ther. 2018 Jan;47(2):192-202
pubmed: 29083037
PLoS One. 2009 Jul 28;4(7):e6386
pubmed: 19636438
Curr Nutr Food Sci. 2013 May 1;9(2):99-107
pubmed: 24353483
Nature. 2013 Aug 8;500(7461):232-6
pubmed: 23842501
Nat Microbiol. 2019 Feb;4(2):293-305
pubmed: 30531976
Gut. 2003 Mar;52(3):370-6
pubmed: 12584218
Cell Host Microbe. 2007 Sep 13;2(3):204
pubmed: 18030708
Biomed Res Int. 2018 Feb 26;2018:4178607
pubmed: 29682542
Front Microbiol. 2018 Aug 21;9:1967
pubmed: 30186272
Nat Immunol. 2017 Jul 19;18(8):851-860
pubmed: 28722709
Nature. 2009 Oct 29;461(7268):1282-6
pubmed: 19865172
Sci Rep. 2017 Jul 31;7(1):6927
pubmed: 28761060
Can J Microbiol. 2018 May;64(5):327-337
pubmed: 29401402
J Hepatol. 2013 May;58(5):1020-7
pubmed: 23183530
J Crohns Colitis. 2016 Nov;10(11):1351-1361
pubmed: 27194533
Pharmacol Res. 2019 Aug;146:104312
pubmed: 31207344
Inflamm Bowel Dis. 2015 Apr;21(4):888-900
pubmed: 25738377
Med Sci (Paris). 2016 May;32(5):461-9
pubmed: 27225918
Gastroenterology. 2008 Feb;134(2):577-94
pubmed: 18242222
Int Immunopharmacol. 2013 Oct;17(2):314-20
pubmed: 23856612
Nat Commun. 2019 Oct 10;10(1):4614
pubmed: 31601814
Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1422-7
pubmed: 23986515
Cell Metab. 2017 Jul 5;26(1):110-130
pubmed: 28625867
J Proteome Res. 2007 Feb;6(2):546-51
pubmed: 17269711
Front Microbiol. 2018 Oct 09;9:2396
pubmed: 30356740
Immunol Cell Biol. 2018 Nov;96(10):1049-1059
pubmed: 29758102
Int J Clin Exp Pathol. 2014 Jul 15;7(8):4557-76
pubmed: 25197329
Inflamm Bowel Dis. 2016 Feb;22(2):487-504
pubmed: 26588090
PLoS One. 2012;7(2):e30696
pubmed: 22363472
PLoS Pathog. 2014 Jun 26;10(6):e1004198
pubmed: 24968145
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5
pubmed: 17699621
Am J Gastroenterol. 2010 Nov;105(11):2420-8
pubmed: 20648002
Appl Microbiol Biotechnol. 2014 Jun;98(12):5619-32
pubmed: 24639205
FEMS Microbiol Lett. 2002 Dec 17;217(2):133-9
pubmed: 12480096
Am J Gastroenterol. 2005 Jul;100(7):1539-46
pubmed: 15984978
Int J Syst Evol Microbiol. 2004 Sep;54(Pt 5):1469-1476
pubmed: 15388697
J Inflamm Res. 2017 Jun 10;10:63-73
pubmed: 28652796
Nat Protoc. 2017 Jul;12(7):1295-1309
pubmed: 28569761
Cell Host Microbe. 2015 May 13;17(5):577-91
pubmed: 25974300
Int J Colorectal Dis. 2005 May;20(3):277-86
pubmed: 15503066
FEMS Immunol Med Microbiol. 2003 Sep 22;38(2):165-72
pubmed: 13129651
Gut. 2005 Dec;54(12):1714-20
pubmed: 15886302
Nature. 2013 Dec 19;504(7480):446-50
pubmed: 24226770
J Clin Microbiol. 2006 Sep;44(9):3172-7
pubmed: 16954244
Microbiome. 2013 Jun 05;1(1):17
pubmed: 24450808
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105
Front Immunol. 2013 Dec 12;4:445
pubmed: 24376446
Gut Pathog. 2014 Aug 30;6:36
pubmed: 25349631