Spina bifida and pediatric cancers.

Adolescent Central Nervous System Neoplasms / epidemiology Child Child, Preschool Denmark / epidemiology Humans Infant Neoplasms / epidemiology Odds Ratio Prevalence Registries Risk Factors Spinal Dysraphism / epidemiology Taiwan / epidemiology Young Adult
Birth defects central nervous system tumors childhood cancer epidemiology folate spina bifida

Journal

Pediatric hematology and oncology
ISSN: 1521-0669
Titre abrégé: Pediatr Hematol Oncol
Pays: England
ID NLM: 8700164

Informations de publication

Date de publication:
Oct 2020
Historique:
pubmed: 5 5 2020
medline: 27 1 2021
entrez: 5 5 2020
Statut: ppublish

Résumé

Spina bifida has been reported to co-occur with pediatric cancer, but comprehensive evaluations remained elusive. We investigated this co-occurrence in two large, population-based studies in Taiwan (N = 1900 cancer cases, 2,077,137 controls) and Denmark (N = 5508 cases, 137,700 controls). Analyses in Denmark were restricted to the period before prenatal diagnostics became available (2004) and pregnancy terminations of fetuses with birth defects became more common. Using national patient and cancer registries, we linked spina bifida and cancer diagnoses among cases and non-cases. The risk of spina bifida among all cancer cases was increased and similar in Denmark [odds ratio (OR)=8.4, 95% confidence interval (CI) 5.1-13.8] and Taiwan (OR = 8.5, 95% CI 4.0-17.8), particularly for central nervous system (CNS) tumors (Denmark: OR = 16.3, 95% CI 8.1-33.0; Taiwan: OR = 26.6, 95% CI 8.5, 83.1), including benign CNS tumors (Denmark: OR = 41.5, 95% CI 21.2, 81.4). These findings suggest the need for comprehensive investigation of shared risk factors in the link between spina bifida and pediatric cancer.

Identifiants

DOI: 10.1080/08880018.2020.1760409 PMID: 32364426 PMC: PMC7577564
pubmed: 32364426
doi: 10.1080/08880018.2020.1760409
pmc: PMC7577564
mid: NIHMS1637317
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

630-636

Subventions

Organisme : NIEHS NIH HHS
ID : R03 ES021643
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA175959
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States

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Auteurs

Julia E Heck (JE)

Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Jonsson Comprehensive Cancer Center, University of California, UCLA, Los Angeles, California, USA.

Pei-Chen Lee (PC)

Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.

Chia-Kai Wu (CK)

Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.

Chung-Yi Li (CY)

Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan.

Di He (D)

Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Noah Federman (N)

Department of Pediatrics, Geffen School of Medicine, University of California, UCLA, Los Angeles, California, USA.

Fei Yu (F)

Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, California, USA.

Jorn Olsen (J)

Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.

Beate Ritz (B)

Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Onyebuchi A Arah (OA)

Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Johnni Hansen (J)

Danish Cancer Society Research Center, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Spina bifida and pediatric cancers.
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Spina bifida and pediatric cancers.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Spina bifida and pediatric cancers.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Spina bifida and pediatric cancers.
questionsmedicales.fr › Régions géographiques › Europe › Pays nordiques et scandinaves › Danemark › Spina bifida and pediatric cancers.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spina bifida and pediatric cancers.
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Spina bifida and pediatric cancers.
questionsmedicales.fr › Tumeurs › Spina bifida and pediatric cancers.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Odds ratio › Spina bifida and pediatric cancers.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Spina bifida and pediatric cancers.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › Spina bifida and pediatric cancers.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Spina bifida and pediatric cancers.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Anomalies du tube neural › Dysraphie spinale › Spina bifida and pediatric cancers.
questionsmedicales.fr › Régions géographiques › Iles › Taïwan › Spina bifida and pediatric cancers.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Spina bifida and pediatric cancers.