Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.
Animals
Autophagy
Cells, Cultured
Female
Hippocampus
/ enzymology
Male
Membrane Glycoproteins
/ metabolism
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins
/ deficiency
Presynaptic Terminals
/ enzymology
Proteolysis
Proteostasis
Signal Transduction
Synaptic Vesicles
/ enzymology
Ubiquitin-Protein Ligases
/ genetics
Ubiquitination
Vesicle-Associated Membrane Protein 2
/ metabolism
E3 ubiquitin ligases
autophagy
bassoon
mouse
neuroscience
parkin
presynapse
ubiquitination
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 05 2020
04 05 2020
Historique:
received:
03
03
2020
accepted:
02
05
2020
pubmed:
5
5
2020
medline:
18
3
2021
entrez:
5
5
2020
Statut:
epublish
Résumé
Mechanisms regulating the turnover of synaptic vesicle (SV) proteins are not well understood. They are thought to require poly-ubiquitination and degradation through proteasome, endo-lysosomal or autophagy-related pathways. Bassoon was shown to negatively regulate presynaptic autophagy in part by scaffolding Atg5. Here, we show that increased autophagy in
Identifiants
pubmed: 32364493
doi: 10.7554/eLife.56590
pii: 56590
pmc: PMC7224700
doi:
pii:
Substances chimiques
Bsn protein, mouse
0
Membrane Glycoproteins
0
Nerve Tissue Proteins
0
Sv2b protein, mouse
0
Vesicle-Associated Membrane Protein 2
0
vesicle-associated membrane protein 2, mouse
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
parkin protein
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Federal Government of Germany
ID : SFB958
Pays : International
Organisme : Federal Government of Germany
ID : SFB779/B09
Pays : International
Organisme : BMBF
ID : 20150065
Pays : International
Informations de copyright
© 2020, Hoffmann-Conaway et al.
Déclaration de conflit d'intérêts
SH, MB, KS, AA, KR, CB, KT, TT, KS, CR, EG, CG, CM No competing interests declared
Références
J Neuroinflammation. 2019 Dec 27;16(1):275
pubmed: 31882005
Int J Biochem Mol Biol. 2013 Mar 31;4(1):1-26
pubmed: 23638318
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19055-60
pubmed: 20956291
J Biol Chem. 2010 Mar 19;285(12):8595-604
pubmed: 20061386
Nature. 2009 Mar 26;458(7237):445-52
pubmed: 19325624
Nat Cell Biol. 2009 Nov;11(11):1305-14
pubmed: 19801973
Front Neurosci. 2017 Apr 06;11:185
pubmed: 28428740
Neuron. 2014 Apr 2;82(1):181-94
pubmed: 24698275
J Biol Chem. 2008 Dec 12;283(50):34696-703
pubmed: 18818210
J Neurosci. 2010 Feb 3;30(5):1798-809
pubmed: 20130189
PLoS Biol. 2016 Sep 29;14(9):e1002563
pubmed: 27684064
Nat Chem Biol. 2009 Feb;5(2):118-26
pubmed: 19136976
J Cell Biol. 2017 Jul 3;216(7):1895-1906
pubmed: 28515275
Cell. 2007 Sep 7;130(5):943-57
pubmed: 17803915
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13354-9
pubmed: 11078524
PLoS One. 2008 Jan 23;3(1):e1487
pubmed: 18213395
Curr Opin Cell Biol. 2010 Apr;22(2):192-8
pubmed: 19962293
Curr Biol. 2003 May 27;13(11):899-910
pubmed: 12781128
J Biol Chem. 2010 Feb 5;285(6):3840-9
pubmed: 19996097
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6504-9
pubmed: 20332206
Exp Cell Res. 1969 Apr;55(1):95-106
pubmed: 5780799
Neuron. 2012 Apr 26;74(2):277-84
pubmed: 22542182
Nat Med. 2015 Dec;21(12):1406-15
pubmed: 26646497
EMBO J. 2013 Apr 3;32(7):954-69
pubmed: 23403927
Nature. 2010 Mar 25;464(7288):529-35
pubmed: 20336135
J Neurosci. 2016 Aug 17;36(33):8668-86
pubmed: 27535913
J Neurosci. 2016 Nov 30;36(48):12243-12258
pubmed: 27903732
Neuron. 2015 Jan 21;85(2):257-73
pubmed: 25611507
Mol Neurodegener. 2017 Apr 11;12(1):29
pubmed: 28399880
J Neurosci. 2019 Mar 20;39(12):2163-2183
pubmed: 30655355
Nat Protoc. 2013 Oct;8(10):1950-60
pubmed: 24051958
Cell. 2014 Feb 13;156(4):825-35
pubmed: 24529383
Autophagy. 2012 Apr;8(4):445-544
pubmed: 22966490
Trends Biochem Sci. 2017 Nov;42(11):873-886
pubmed: 28947091
J Biol Chem. 2002 Mar 22;277(12):10273-82
pubmed: 11786535
Nature. 2006 Jun 15;441(7095):880-4
pubmed: 16625205
Nature. 1988 Nov 10;336(6195):185-6
pubmed: 3185736
Cell Rep. 2016 Oct 18;17(4):1071-1086
pubmed: 27720640
Nat Med. 2013 Aug;19(8):983-97
pubmed: 23921753
Mol Cell Neurosci. 2017 Apr;80:89-99
pubmed: 28254618
Nature. 2006 Jun 15;441(7095):885-9
pubmed: 16625204
Methods Cell Biol. 2003;71:111-27
pubmed: 12884689
Neuron. 2003 Mar 6;37(5):787-800
pubmed: 12628169
EMBO J. 2018 Aug 1;37(15):
pubmed: 29950309
Trends Cell Biol. 2017 Jul;27(7):491-504
pubmed: 28169082
Neuron. 2017 Feb 22;93(4):897-913.e7
pubmed: 28231469
Mol Cell. 2013 Aug 8;51(3):283-96
pubmed: 23911927
Elife. 2019 May 10;8:
pubmed: 31074746
J Cereb Blood Flow Metab. 2018 Nov;38(11):1924-1939
pubmed: 29972341
Nat Med. 2001 Oct;7(10):1144-50
pubmed: 11590439
J Cell Biol. 2007 Sep 10;178(6):1025-38
pubmed: 17846173
Am J Pathol. 2007 Aug;171(2):513-24
pubmed: 17620365
Curr Opin Genet Dev. 2017 Jun;44:38-46
pubmed: 28213157
J Neurosci. 2013 Mar 6;33(10):4456-67
pubmed: 23467361
EMBO J. 2014 Nov 3;33(21):2473-91
pubmed: 25216678
Hum Mol Genet. 2003 Oct 15;12(20):2587-97
pubmed: 12925569
J Neurosci. 2010 Mar 3;30(9):3157-66
pubmed: 20203175
Neuron. 2010 Nov 18;68(4):724-38
pubmed: 21092861
Bioessays. 2008 Nov;30(11-12):1075-83
pubmed: 18937340
Physiol Rev. 2011 Oct;91(4):1161-218
pubmed: 22013209
Mol Cell. 2009 Dec 25;36(6):1034-47
pubmed: 20064468
J Biosci. 2006 Mar;31(1):137-55
pubmed: 16595883
Mol Cell Proteomics. 2014 Sep;13(9):2513-26
pubmed: 24942700
Brain. 2017 Sep 1;140(9):2265-2272
pubmed: 28335015
Front Mol Neurosci. 2017 May 22;10:148
pubmed: 28588450
Curr Opin Neurobiol. 2018 Feb;48:113-121
pubmed: 29274917
Neuron. 2005 Sep 1;47(5):629-32
pubmed: 16129392
J Neurosci. 2011 Jul 13;31(28):10189-200
pubmed: 21752995
Nat Rev Mol Cell Biol. 2011 Dec 14;13(1):7-12
pubmed: 22166994
Physiol Rev. 2010 Oct;90(4):1383-435
pubmed: 20959619
Neuron. 2010 Nov 18;68(4):710-23
pubmed: 21092860
Autophagy. 2014 Apr;10(4):549-51
pubmed: 24657946
Mol Cells. 2017 Jul 31;40(7):441-449
pubmed: 28743182
Nat Chem Biol. 2011 Jan;7(1):9-17
pubmed: 21164513
J Cell Biol. 2014 Sep 1;206(5):655-70
pubmed: 25154397
Mol Cell Neurosci. 2003 Jun;23(2):279-91
pubmed: 12812759
Nat Chem Biol. 2014 Dec;10(12):1013-9
pubmed: 25326666
PLoS Biol. 2006 Sep;4(9):e271
pubmed: 16903782
Curr Biol. 2018 Apr 2;28(7):1027-1038.e4
pubmed: 29551411