Total Synthesis of Dictyodendrins A-F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole.
cascade reactions
conjugated diyne
dictyodendrins
gold catalysts
pyrrolocarbazole
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
21
04
2020
revised:
30
04
2020
pubmed:
5
5
2020
medline:
5
5
2020
entrez:
5
5
2020
Statut:
ppublish
Résumé
The total synthesis of dictyodendrins A-F was achieved by using the gold(I)-catalyzed annulation of a conjugated diyne with N-Boc-pyrrole for direct construction of the pyrrolo[2,3-c]carbazole scaffold. Late-stage functionalization of the resulting pyrrolo[2,3-c]carbazole to introduce various substituents provided divergent access to dictyodendrins. Some dictyodendrin analogues exhibited inhibitory activities toward CDK2/CycA2 and GSK3.
Identifiants
pubmed: 32364649
doi: 10.1002/chem.202001950
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11150-11157Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP17H03971
Organisme : Japan Society for the Promotion of Science
ID : JP18H04408
Organisme : Japan Society for the Promotion of Science
ID : JP18J12107
Organisme : Japan Agency for Medical Research and Development
ID : JP19am0101092j0001
Organisme : Tokyo Biochemical Research Foundation
Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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