L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
CD62L
L-Selectin
NASH
insulin resistance
non-alcoholic steatohepatitis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 04 2020
29 04 2020
Historique:
received:
04
04
2020
revised:
20
04
2020
accepted:
27
04
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
30
3
2021
Statut:
epublish
Résumé
CD62L (L-Selectin) dependent lymphocyte infiltration is known to induce inflammatory bowel disease (IBD), while its function in the liver, especially in non-alcoholic steatohepatitis (NASH), remains unclear. We here investigated the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis. Hepatic expression of a soluble form of CD62L (sCD62L) was measured in patients with steatosis and NASH. Furthermore, CD62L
Identifiants
pubmed: 32365632
pii: cells9051106
doi: 10.3390/cells9051106
pmc: PMC7290433
pii:
doi:
Substances chimiques
L-Selectin
126880-86-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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