Inhibition of UDP-glucuronosyltransferases by different furoquinoline alkaloids.

Alkaloids Computer Simulation Enzyme Inhibitors / metabolism Glucuronosyltransferase / metabolism Herb-Drug Interactions Humans Hymecromone / metabolism Molecular Docking Simulation Quinolines
Furoquinoline alkaloids UDP-glucuronosyltransferases (UGTs) dictamnine haplopine herb–drug interactions (HDIs) skimmianine γ-fagarine

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Oct 2020
Historique:
pubmed: 6 5 2020
medline: 9 9 2020
entrez: 6 5 2020
Statut: ppublish

Résumé

Herbs are often administered in combination with therapeutic drugs, raising the possibility for herb-drug interactions (HDIs). Furoquinoline alkaloids are found in Rutaceae plants, which are structurally similar and have many medicinal properties. This study aims to investigate the inhibition of four furoquinoline alkaloids on the activity of UDP-glucuronosyltransferases (UGTs).The recombinant UGTs-catalyzed glucuronidation metabolism of 4-methylumbelliferone (4-MU) was utilized to investigate the inhibition potential. Inhibition type and parameters were determined, and

Identifiants

DOI: 10.1080/00498254.2020.1760400 PMID: 32367776
pubmed: 32367776
doi: 10.1080/00498254.2020.1760400
doi:

Substances chimiques

Alkaloids 0
Enzyme Inhibitors 0
Quinolines 0
Hymecromone 3T5NG4Q468
skimmianine 4E1KLC380B
gamma-fagarine 524-15-2
Glucuronosyltransferase EC 2.4.1.17

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1170-1179

Auteurs

Yixuan Li (Y)

School of integrative medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.

Weihua Zhang (W)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.

Tingting Yin (T)

School of integrative medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.

Ce Wang (C)

Basic Medical College, Hebei North University, Hebei, China.

Feige Wang (F)

School of integrative medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Jing Sun (J)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.

Lina Liu (L)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.

Qinghuai Zhang (Q)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.

Chunze Zhang (C)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
State Key Laboratory of Medicinal Chemical Biology, NanKai University, Tianjin, China.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Interactions médicaments-plantes › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › Ombelliférones › Hymécromone › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Inhibition of UDP-glucuronosyltransferases by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Inhibition of UDP-glucuronosyltransferases by...