The neonatal Fc receptor in cancer FcRn in cancer.
FCGRT
Neonatal Fc receptor
antigen presentation
cancer
cancer prognosis
cross-presentation
immune complexes
immunosurveillance
tumor metabolism
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
12
12
2019
revised:
30
03
2020
accepted:
31
03
2020
pubmed:
6
5
2020
medline:
4
5
2021
entrez:
6
5
2020
Statut:
ppublish
Résumé
Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data show that FcRn plays a part in cancer pathophysiology. In various types of cancers, such as lung and colorectal cancer, FcRn has been described as an early marker for prognosis. Dysregulation of FcRn expression by cancer cells allows them to increase their metabolism, and this process could be exploited for passive targeting of cytotoxic drugs. However, the roles of this receptor depend on whether the studied cell population is the tumor tissue or the infiltrating cells, bringing forward the need for further studies.
Identifiants
pubmed: 32368865
doi: 10.1002/cam4.3067
pmc: PMC7333860
doi:
Substances chimiques
Biomarkers, Tumor
0
Histocompatibility Antigens Class I
0
Receptors, Fc
0
Fc receptor, neonatal
TW3XAW0RCY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4736-4742Informations de copyright
© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
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