Primary Ewing sarcoma of the lung diagnosed on cytology: Case report with review of literature.
12E7 Antigen
/ metabolism
Cyclophosphamide
/ therapeutic use
Doxorubicin
/ therapeutic use
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lung
/ pathology
Lung Neoplasms
/ diagnosis
Male
Middle Aged
Proto-Oncogene Protein c-fli-1
/ metabolism
RNA-Binding Protein EWS
/ genetics
Sarcoma, Ewing
/ diagnosis
Vincristine
/ therapeutic use
Ewing sarcoma
FISH
IHC
fine-needle aspiration cytology
lung
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
07
01
2020
revised:
15
04
2020
accepted:
21
04
2020
pubmed:
6
5
2020
medline:
15
10
2021
entrez:
6
5
2020
Statut:
ppublish
Résumé
Primary Ewing sarcoma (ES) of the lung is anecdotally rare, with few cases reported in literature. This report describes a 46 year-old man who presented with cough and chest pain. CT Thorax revealed a lesion in the right lung. Ultrasound guided fine-needle aspiration of the mass and subsequent cytologic examination exhibited a small round cell morphology. Immunohistochemistry done on the cell block revealed CD 99 and FLI-1 positivity, confirming the diagnosis of ES. FISH supported the diagnosis, showing the EWSR1 rearrangement. Radiologic investigations ruled out a primary tumour elsewhere, confirming the diagnosis of primary pulmonary ES. The patient was started on chemotherapy.
Substances chimiques
12E7 Antigen
0
CD99 protein, human
0
EWSR1 protein, human
0
FLI1 protein, human
0
Proto-Oncogene Protein c-fli-1
0
RNA-Binding Protein EWS
0
Vincristine
5J49Q6B70F
Doxorubicin
80168379AG
Cyclophosphamide
8N3DW7272P
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1098-1101Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
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