Caught in the act: structural dynamics of replication origin activation and fork progression.

Adenosine Triphosphatases / metabolism Cell Cycle Computer Simulation Cryoelectron Microscopy / methods DNA / chemistry DNA Replication Eukaryota Hydrolysis In Vitro Techniques Protein Conformation Replication Origin Single Molecule Imaging
in silico reconstitution DNA replication biochemistry cryo-electron microscopy single molecule

Journal

Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897

Informations de publication

Date de publication:
30 06 2020
Historique:
received: 15 02 2020
revised: 09 04 2020
accepted: 14 04 2020
pubmed: 6 5 2020
medline: 20 2 2021
entrez: 6 5 2020
Statut: ppublish

Résumé

This review discusses recent advances in single-particle cryo-EM and single-molecule approaches used to visualise eukaryotic DNA replication reactions reconstituted in vitro. We comment on the new challenges facing structural biologists, as they turn to describing the dynamic cascade of events that lead to replication origin activation and fork progression.

Identifiants

DOI: 10.1042/BST20190998 PMID: 32369549 PMC: PMC7329347
pubmed: 32369549
pii: 223816
doi: 10.1042/BST20190998
pmc: PMC7329347
doi:

Substances chimiques

DNA 9007-49-2
Adenosine Triphosphatases EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1057-1066

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom

Informations de copyright

© 2020 The Author(s).

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Auteurs

Jacob S Lewis (JS)

Macromolecular Machines Laboratory, The Francis Crick Institute, London NW1 1AT, U.K.

Alessandro Costa (A)

Macromolecular Machines Laboratory, The Francis Crick Institute, London NW1 1AT, U.K.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › Adenosine triphosphatases › Caught in the act: structural dynamics of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Caught in the act: structural dynamics of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Caught in the act: structural dynamics of...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Caught in the act: structural dynamics of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Caught in the act: structural dynamics of...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Caught in the act: structural dynamics of...
questionsmedicales.fr › Eucaryotes › Caught in the act: structural dynamics of...
questionsmedicales.fr › Phénomènes chimiques › Hydrolyse › Caught in the act: structural dynamics of...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Caught in the act: structural dynamics of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Caught in the act: structural dynamics of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Réplicon › Origine de réplication › Caught in the act: structural dynamics of...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Imagerie moléculaire › Imagerie de molécules uniques › Caught in the act: structural dynamics of...