A new standardized phytoextract from red orange and lemon wastes (red orange and lemon extract) reduces basophil degranulation and activation.

Basophil Degranulation Test Basophils Citrus Flow Cytometry Plant Extracts / pharmacology Tetraspanin 30
CD203c CD63 Citrus fruit Red Orange antiallergic lemon

Journal

Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924

Informations de publication

Date de publication:
Dec 2021
Historique:
pubmed: 7 5 2020
medline: 15 12 2021
entrez: 7 5 2020
Statut: ppublish

Résumé

Citrus fruits are rich sources of bioactive compounds and their consumption is associated to health-promoting effects. Citrus processing wastes contain bioflavonoids and other high added value compounds. The aim of this study was to evaluate the antiallergic properties of a new phytoextract obtained by citrus wastes and peels. Blood orange and lemon processing wastes were used to produce a Red orange and Lemon Extract (RLE). Blood samples from 30 allergic donors were collected and used to evaluate the basophil activation (CD203c) and degranulation (CD63) by stimulation trough allergen with and without the RLE. Reduced basophil expression of CD203c and CD63 were observed in RLE + Allergen treated samples, with -20.21% of CD203c expression (

Identifiants

DOI: 10.1080/14786419.2020.1761355 PMID: 32370569
pubmed: 32370569
doi: 10.1080/14786419.2020.1761355
doi:

Substances chimiques

Plant Extracts 0
Tetraspanin 30 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5354-5359

Auteurs

Massimo Caruso (M)

Department of Biomedical Sciences and Biotechnology (BIOMETEC), University of Catania, Catania, Italy.
Department of Clinical and Experimental Medicine (MEDCLIN), University of Catania, Catania, Italy.

Simona Fabroni (S)

Research Centre for Olive, Citrus and Tree Fruit, Council for Agricultural Research and Economics (CREA), Acireale, Italy.

Rosalia Emma (R)

Department of Biomedical Sciences and Biotechnology (BIOMETEC), University of Catania, Catania, Italy.

Gabriele Ballistreri (G)

Research Centre for Olive, Citrus and Tree Fruit, Council for Agricultural Research and Economics (CREA), Acireale, Italy.
ORCID: 0000-0002-1835-0047

Margherita Amenta (M)

Research Centre for Olive, Citrus and Tree Fruit, Council for Agricultural Research and Economics (CREA), Acireale, Italy.

Walter Currenti (W)

Department of Biomedical Sciences and Biotechnology (BIOMETEC), University of Catania, Catania, Italy.

Calogero Rinzivillo (C)

Clinical Nutrition & Integrated Supportive Therapy-Department of Medical-Surgical Sciences & Advanced Technology, Hospital University "Policlinico-Vittorio Emanuele", Catania, Italy.

Paolo Rapisarda (P)

Research Centre for Olive, Citrus and Tree Fruit, Council for Agricultural Research and Economics (CREA), Acireale, Italy.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Test de dégranulation des basophiles › A new standardized phytoextract from red...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes basophiles › A new standardized phytoextract from red...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rutaceae › Citrus › A new standardized phytoextract from red...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › A new standardized phytoextract from red...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › A new standardized phytoextract from red...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Antigène CD63 › A new standardized phytoextract from red...