Vascular injury biomarkers and stroke risk: A population-based study.

Adult Aged Antigens, CD / blood Biomarkers / blood Cell Adhesion Molecules / blood Cohort Studies Female Follow-Up Studies Germany / epidemiology Humans Male Middle Aged Population Surveillance / methods Prospective Studies Risk Factors Stroke / blood Vascular System Injuries / blood

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
02 06 2020
Historique:
received: 14 03 2019
accepted: 27 11 2019
pubmed: 7 5 2020
medline: 12 9 2020
entrez: 7 5 2020
Statut: ppublish

Résumé

Because little is known about associations between biomarkers of vascular injury and stroke risk, we evaluated associations between plasma concentrations of 6 novel biomarkers of vascular injury and stroke risk in a population-based study. A case-cohort subset of EPIC-Heidelberg (European Prospective Investigation for Cancer and Nutrition-Heidelberg) including incident stroke cases (n = 335) and a random subcohort (n = 2,418) was selected. Concentrations of intercellular adhesion molecule 3 (ICAM3), soluble E-selectin and P-selectin, soluble thrombomodulin (sTM), thrombopoietin, and glycoprotein IIb/IIIa were measured in baseline plasma samples. Weighted Cox regression analyses were used to assess associations between biomarker levels and stroke risk. Median follow-up in the subcohort and among cases was 9.8 (range, 0.1-12.5) years and 6.2 (range, 0.01-12.1) years, respectively. ICAM3 levels were associated with increased risk of incident stroke after multivariable adjustment (hazard ratio, highest vs lowest quartile: 1.64 [95% confidence interval, 1.15-2.32]; In this population-based study, circulating levels of ICAM3, an adhesion molecule shed by leukocytes, were associated with increased risk of incident stroke. Further mechanistic studies are needed to elucidate the pathophysiology underlying this association. This study provides Class II evidence that plasma levels of ICAM3 are associated with increased stroke risk.

Identifiants

DOI: 10.1212/WNL.0000000000009391 PMID: 32371447
pubmed: 32371447
pii: WNL.0000000000009391
doi: 10.1212/WNL.0000000000009391
doi:

Substances chimiques

Antigens, CD 0
Biomarkers 0
Cell Adhesion Molecules 0
ICAM3 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2337-e2345

Informations de copyright

© 2020 American Academy of Neurology.

Auteurs

Laura Pletsch-Borba (L)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.
ORCID: 0000-0003-4872-6452

Mirja Grafetstätter (M)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Anika Hüsing (A)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Theron Johnson (T)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Sandra González Maldonado (S)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Marie-Luise Groß (ML)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Manja Kloss (M)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Michael Hoffmeister (M)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Peter Bugert (P)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Rudolf Kaaks (R)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Tilman Kühn (T)

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany. t.kuehn@dkfz.de.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Vascular injury biomarkers and stroke risk: A...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Vascular injury biomarkers and stroke risk: A...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Surveillance de la population › Vascular injury biomarkers and stroke risk: A...
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questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Vascular injury biomarkers and stroke risk: A...
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