Identification of an Amygdala-Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions.
amygdala
fMRI
gustation
perception
taste intensity
thalamus
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
24 06 2020
24 06 2020
Historique:
received:
04
11
2019
revised:
10
02
2020
accepted:
19
03
2020
pubmed:
7
5
2020
medline:
21
11
2020
entrez:
7
5
2020
Statut:
ppublish
Résumé
Peripheral sources of individual variation in taste intensity perception have been well described. The existence of a central source has been proposed but remains unexplored. Here we used functional magnetic resonance imaging in healthy human participants (20 women, 8 men) to evaluate the hypothesis that the amygdala exerts an inhibitory influence that affects the "gain" of the gustatory system during tasting. Consistent with the existence of a central gain mechanism (CGM), we found that central amygdala response was correlated with mean intensity ratings across multiple tastants. In addition, psychophysiological and dynamic causal modeling analyses revealed that the connection strength between inhibitory outputs from amygdala to medial dorsal and ventral posterior medial thalamus predicted individual differences in responsiveness to taste stimulation. These results imply that inhibitory inputs from the amygdala to the thalamus act as a CGM that influences taste intensity perception.
Identifiants
pubmed: 32371606
pii: JNEUROSCI.2618-19.2020
doi: 10.1523/JNEUROSCI.2618-19.2020
pmc: PMC7314406
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5051-5062Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC006706
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS041228
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 the authors.
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