Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process.
Bleomycin
Inflammation
Natural compound
Pulmonary fibrosis
Tannic acid
Transforming growth factor-β
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
16
01
2020
accepted:
09
04
2020
pubmed:
7
5
2020
medline:
2
7
2021
entrez:
7
5
2020
Statut:
ppublish
Résumé
Pulmonary fibrosis (PF) is a chronic and irreversible scarring disease in the lung with limited treatment options. Therefore, it is critical to identify new therapeutic options. This study was undertaken to identify the effects of tannic acid (TA), a naturally occurring dietary polyphenol, in a mouse model of PF. Bleomycin (BLM) was intratracheally administered to induce PF. Administration of TA significantly reduced BLM-induced histological alterations, inflammatory cell infiltration and the levels of various inflammatory mediators (nitric oxide, leukotriene B
Identifiants
pubmed: 32372165
doi: 10.1007/s10787-020-00707-5
pii: 10.1007/s10787-020-00707-5
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Inflammation Mediators
0
Tannins
0
Bleomycin
11056-06-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1301-1314Subventions
Organisme : Department of Biotechnology , Ministry of Science and Technology
ID : BT/RLF/Re-entry/36/2013
Organisme : Science and Engineering Research Board
ID : YSS/2014/000125
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