Tumor microenvironment-responsive multifunctional peptide coated ultrasmall gold nanoparticles and their application in cancer radiotherapy.
Tat peptide
cancer radiotherapy
enzyme-responsive
ultrasmall gold nanoparticles
zwitterionic peptide
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
02
2020
accepted:
22
03
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
27
7
2021
Statut:
epublish
Résumé
Two important features are required for promising radiosensitizers: one is selective tumor cell targeting to enhance the therapeutic outcome via lethal DNA damage and the other is rapid clearance to enable excellent biocompatibility for potential clinical application. Herein, ultrasmall gold nanoparticles (Au NPs) with diameter smaller than 5 nm were prepared and covered with a multifunctional peptide to endow them with selective tumor cell uptake capability. Combined with X-ray irradiation, the responsive Au NPs demonstrated superior radio-sensitizing toxicity and rapid renal clearance
Identifiants
pubmed: 32373207
doi: 10.7150/thno.45017
pii: thnov10p5195
pmc: PMC7196283
doi:
Substances chimiques
Reactive Oxygen Species
0
Gold
7440-57-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5195-5208Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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