'Design, synthesis, and strategic use of small chemical probes toward identification of novel targets for drug development'.
Clustered Regularly Interspaced Short Palindromic Repeats
/ genetics
Drug Evaluation, Preclinical
Humans
Limonins
/ chemistry
Machine Learning
Molecular Targeted Therapy
Proteomics
Small Molecule Libraries
/ chemistry
Structure-Activity Relationship
Thalidomide
/ chemistry
Ubiquitin-Protein Ligases
/ metabolism
CETSA
Chemical probes
Chemical proteomics
Chemogenomics libraries
LiP
Molecular glues
Phenotypic screens
Target identification
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
16
11
2019
revised:
10
03
2020
accepted:
10
03
2020
pubmed:
7
5
2020
medline:
18
5
2021
entrez:
7
5
2020
Statut:
ppublish
Résumé
Chemical probes are essential tools used to study and modulate biological systems. Here, we describe some of the recent scientific advancement in the field of chemical biology, as well as how the advent of new technologies is redefining the criteria of 'good' chemical probes and influencing the discovery of valuable drug leads. In this review, we report selected examples of the usage of linkered and linker-free chemical probes for target identification, biological discovery, and general mechanistic understanding. We also discuss the promises of chemogenomics libraries in phenotypic screens, as well as the limitation of their usage to identify the modulation of new targets and biology.
Identifiants
pubmed: 32375076
pii: S1367-5931(20)30034-X
doi: 10.1016/j.cbpa.2020.03.003
pii:
doi:
Substances chimiques
Limonins
0
Small Molecule Libraries
0
nimbolide
25990-37-8
Thalidomide
4Z8R6ORS6L
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
91-97Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Conflict of interest statement Nothing declared.