Effects of
Animals
Anthocyanins
/ administration & dosage
Autophagy
Body Weight
Diet, High-Fat
/ adverse effects
Dietary Supplements
Disease Models, Animal
Down-Regulation
Endoplasmic Reticulum Stress
Fatty Liver
/ etiology
Fruit and Vegetable Juices
Gene Expression
Male
Membrane Glycoproteins
/ genetics
Microtubule-Associated Proteins
/ genetics
Obesity
/ etiology
Phytochemicals
/ administration & dosage
Phytotherapy
Protein Folding
Prunus avium
Rats, Wistar
Seeds
anthocyanins
diet-induced obese rats
liver
obesity
tart cherry
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
04 May 2020
04 May 2020
Historique:
received:
21
03
2020
revised:
24
04
2020
accepted:
26
04
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
18
2
2021
Statut:
epublish
Résumé
The accumulation of adipose tissue increases the risk of several diseases. The fruits-intake, containing phytochemicals, is inversely correlated with their development. This study evaluated the effects of anthocyanin-rich tart cherries in diet-induced obese (DIO) rats. DIO rats were exposed to a high-fat diet with the supplementation of tart cherry seeds powder (DS) and seed powder plus juice (DJS). After 17 weeks, the DIO rats showed an increase of body weight, glycaemia, insulin, and systolic blood pressure. In the DS and DJS groups, there was a decrease of systolic blood pressure, glycaemia, triglycerides, and thiobarbituric reactive substances in the serum. In the DJS rats, computed tomography revealed a decrease in the spleen-to-liver attenuation ratio. Indeed, sections of the DIO rats presented hepatic injury characterized by steatosis, which was lower in the supplemented groups. In the liver of the DIO compared with rats fed with a standard diet (CHOW), a down-regulation of the GRP94 protein expression and a reduction of LC3- II/LC3-I ratio were found, indicating endoplasmic reticulum stress and impaired autophagy flux. Interestingly, tart cherry supplementation enhanced both unfolded protein response (UPR) and autophagy. This study suggests that tart cherry supplementation, although it did not reduce body weight in the DIO rats, prevented its related risk factors and liver steatosis.
Identifiants
pubmed: 32375317
pii: nu12051308
doi: 10.3390/nu12051308
pmc: PMC7285149
pii:
doi:
Substances chimiques
Anthocyanins
0
LC3 protein, rat
0
Membrane Glycoproteins
0
Microtubule-Associated Proteins
0
Phytochemicals
0
endoplasmin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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