The prognostic value of preoperative fibrinogen-to-prealbumin ratio and a novel FFC score in patients with resectable gastric cancer.
FFC score
Fibrinogen-to-albumin ratio
Fibrinogen-to-prealbumin ratio
Gastric cancer
Inflammation
Prognostic factor
Journal
BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800
Informations de publication
Date de publication:
06 May 2020
06 May 2020
Historique:
received:
12
11
2019
accepted:
14
04
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
3
2
2021
Statut:
epublish
Résumé
Chronic inflammation is considered as a hallmark of gastric cancer (GC) and plays a critical role in GC progression and metastasis. This study aimed to explore the prognostic values of preoperative fibrinogen-to-prealbumin ratio (FPR), fibrinogen-to-albumin ratio (FAR), and novel FPR-FAR-CEA (FFC) score in patients with GC undergoing gastrectomy. A total of 273 patients with resectable GC were included in this retrospective study. We performed Kaplan-Meier and Cox regression analyses to assess the prognostic role of preoperative FPR, FAR, and FFC score in patients with GC and analyze their relationships with clinicopathological features. Receiver operating characteristic curve (ROC) analysis revealed that the optimal cutoff values for FPR and FAR were 0.0145 and 0.0784, respectively. The FFC score had a higher area under the ROC curve than FAR and CEA. Elevated FPR (≥ 0.0145) and FAR (≥ 0.0784) were significantly associated with old age, large tumor size, tumor invasion depth, lymph nodes metastasis, advanced TNM stage, large Borrmann type, and anemia status. Kaplan-Meier analysis showed that high FPR, FAR, and FFC score were related to poor survival. Multivariate analyses indicated that FPR, FFC score, TNM stage, and tumor size were significant independent factors for survival. Preoperative FPR and FFC score could be used as prospective noninvasive prognostic biomarkers for resectable GC.
Sections du résumé
BACKGROUND
BACKGROUND
Chronic inflammation is considered as a hallmark of gastric cancer (GC) and plays a critical role in GC progression and metastasis. This study aimed to explore the prognostic values of preoperative fibrinogen-to-prealbumin ratio (FPR), fibrinogen-to-albumin ratio (FAR), and novel FPR-FAR-CEA (FFC) score in patients with GC undergoing gastrectomy.
METHODS
METHODS
A total of 273 patients with resectable GC were included in this retrospective study. We performed Kaplan-Meier and Cox regression analyses to assess the prognostic role of preoperative FPR, FAR, and FFC score in patients with GC and analyze their relationships with clinicopathological features.
RESULTS
RESULTS
Receiver operating characteristic curve (ROC) analysis revealed that the optimal cutoff values for FPR and FAR were 0.0145 and 0.0784, respectively. The FFC score had a higher area under the ROC curve than FAR and CEA. Elevated FPR (≥ 0.0145) and FAR (≥ 0.0784) were significantly associated with old age, large tumor size, tumor invasion depth, lymph nodes metastasis, advanced TNM stage, large Borrmann type, and anemia status. Kaplan-Meier analysis showed that high FPR, FAR, and FFC score were related to poor survival. Multivariate analyses indicated that FPR, FFC score, TNM stage, and tumor size were significant independent factors for survival.
CONCLUSIONS
CONCLUSIONS
Preoperative FPR and FFC score could be used as prospective noninvasive prognostic biomarkers for resectable GC.
Identifiants
pubmed: 32375697
doi: 10.1186/s12885-020-06866-6
pii: 10.1186/s12885-020-06866-6
pmc: PMC7201974
doi:
Substances chimiques
Biomarkers, Tumor
0
Prealbumin
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
382Subventions
Organisme : National Natural Science Foundation of China
ID : 81872427
Organisme : National Natural Science Foundation of China
ID : 81672428
Organisme : Haiyan Fund Project of Harbin Medical University Cancer Hospital
ID : JJQN2019-02
Organisme : Haiyan Fund Project of Harbin Medical University Cancer Hospital
ID : JJZD2020-17
Organisme : Health Commission of Heilongjiang
ID : 2019-060
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