Human BST-2/tetherin inhibits Junin virus release from host cells and its inhibition is partially counteracted by viral nucleoprotein.
A549 Cells
Antigens, CD
/ metabolism
Antiviral Agents
/ pharmacology
Cell Line
Cell Line, Tumor
GPI-Linked Proteins
/ metabolism
HEK293 Cells
HeLa Cells
Host-Pathogen Interactions
/ drug effects
Humans
Interferons
/ pharmacology
Junin virus
/ drug effects
Nucleoproteins
/ metabolism
Viral Core Proteins
/ metabolism
Virus Release
/ drug effects
Virus Replication
/ drug effects
Arenaviridae
Junin virus
Tetherin
human BST-2
innate immunity
Journal
The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
8
5
2020
medline:
27
10
2020
entrez:
8
5
2020
Statut:
ppublish
Résumé
Bone marrow stromal cell antigen-2 (BST-2), also known as tetherin, is an interferon-inducible membrane-associated protein. It effectively targets enveloped viruses at the release step of progeny viruses from host cells, thereby restricting the further spread of viral infection. Junin virus (JUNV) is a member of
Identifiants
pubmed: 32375950
doi: 10.1099/jgv.0.001414
doi:
Substances chimiques
Antigens, CD
0
Antiviral Agents
0
BST2 protein, human
0
GPI-Linked Proteins
0
Nucleoproteins
0
Viral Core Proteins
0
nucleoprotein VP40, Ebola virus
0
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM