Polymethoxyflavones from Gardenia oudiepe (Rubiaceae) induce cytoskeleton disruption-mediated apoptosis and sensitize BRAF-mutated melanoma cells to chemotherapy.
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Caspase 3
/ metabolism
Cell Cycle Checkpoints
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Cytoskeleton
/ drug effects
Drug Synergism
Enzyme Activation
/ drug effects
Flavones
/ chemistry
Gardenia
/ chemistry
Humans
Melanoma
/ pathology
Molecular Docking Simulation
Mutation
Protein Conformation
Proto-Oncogene Proteins B-raf
/ genetics
Structure-Activity Relationship
Tubulin
/ chemistry
Apoptosis
Cancer
Cytoskeleton
Flavonoids
Melanoma
Multidrug resistance
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
10
02
2020
revised:
18
03
2020
accepted:
13
04
2020
pubmed:
8
5
2020
medline:
17
6
2020
entrez:
8
5
2020
Statut:
ppublish
Résumé
A series of 10 natural and semisynthetic flavonoids (1 to 10) were obtained from Gardenia oudiepe (Rubiaceae), an endemic plant from New Caledonia. Most of them were polymethoxylated flavones (PMFs) of rare occurrence. After a cell viability screening test, PMFs 2 and 3 showed significant cytotoxic activity against A2058 human melanoma cells (IC
Identifiants
pubmed: 32376239
pii: S0009-2797(20)30211-8
doi: 10.1016/j.cbi.2020.109109
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Flavones
0
Tubulin
0
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Caspase 3
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109109Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.