Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges.
Addiction
Analgesia
Dopamine D3 receptor
Drug self-administration
Opioid use disorder
Relapse
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
22
04
2020
accepted:
28
04
2020
pubmed:
8
5
2020
medline:
22
6
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Opioid abuse and related overdose deaths continue to rise in the United States, contributing to the current national opioid crisis. Although several opioid-based pharmacotherapies are available (e.g., methadone, buprenorphine, naloxone), they show limited effectiveness in long-term relapse prevention. In response to the opioid crisis, the National Institute on Drug Abuse proposed a list of pharmacological targets of highest priority for medication development for the treatment of opioid use disorders (OUD). Among these are antagonists of dopamine D3 receptors (D3R). In this review, we first review recent progress in research of the dopamine hypothesis of opioid reward and abuse and then describe the rationale and recent development of D3R ligands for the treatment of OUD. Herein, an emphasis is placed on the effectiveness of newly developed D3R antagonists in the animal models of OUD. These new drug candidates may also potentiate the analgesic effects of clinically used opioids, making them attractive as adjunctive medications for pain management and treatment of OUD.
Identifiants
pubmed: 32376243
pii: S0149-7634(20)30389-4
doi: 10.1016/j.neubiorev.2020.04.024
pmc: PMC7252042
mid: NIHMS1590527
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Receptors, Dopamine D3
0
Buprenorphine
40D3SCR4GZ
Methadone
UC6VBE7V1Z
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-52Subventions
Organisme : Intramural NIH HHS
ID : Z99 DA999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DA000620
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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