Neural correlates of working memory training: Evidence for plasticity in older adults.
Aged
Aging
/ physiology
Brain
/ diagnostic imaging
Brain Mapping
Cognition
/ physiology
Executive Function
/ physiology
Female
Humans
Learning
Magnetic Resonance Imaging
Male
Memory, Short-Term
/ physiology
Nerve Net
/ diagnostic imaging
Neural Pathways
/ diagnostic imaging
Neuronal Plasticity
/ physiology
Psychomotor Performance
Young Adult
Aging
Cognitive training
Default-mode
Executive functions
Fronto-parietal
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
20
08
2019
revised:
26
02
2020
accepted:
26
04
2020
pubmed:
8
5
2020
medline:
20
2
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Brain activity typically increases with increasing working memory (WM) load, regardless of age, before reaching an apparent ceiling. However, older adults exhibit greater brain activity and reach ceiling at lower loads than younger adults, possibly reflecting compensation at lower loads and dysfunction at higher loads. We hypothesized that WM training would bolster neural efficiency, such that the activation peak would shift towards higher memory loads after training. Pre-training, older adults showed greater recruitment of the WM network than younger adults across all loads, with decline at the highest load. Ten days of adaptive training on a verbal WM task improved performance and led to greater brain responsiveness at higher loads for both groups. For older adults the activation peak shifted rightward towards higher loads. Finally, training increased task-related functional connectivity in older adults, both within the WM network and between this task-positive network and the task-negative/default-mode network. These results provide new evidence for functional plasticity with training in older adults and identify a potential signature of improvement at the neural level.
Identifiants
pubmed: 32376302
pii: S1053-8119(20)30373-6
doi: 10.1016/j.neuroimage.2020.116887
pmc: PMC7755422
mid: NIHMS1652524
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
116887Subventions
Organisme : NIA NIH HHS
ID : R21 AG045460
Pays : United States
Organisme : NIH HHS
ID : S10 OD012240
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG000247
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest M.B. is employed at the MIND Research Institute, whose interest is related to this work. S.M.J. has an indirect financial interest in the MIND Research Institute. None of the other authors declare any competing interests.
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