Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host.
Journal
Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
06
12
2019
revised:
30
03
2020
accepted:
07
04
2020
pubmed:
8
5
2020
medline:
21
10
2020
entrez:
8
5
2020
Statut:
ppublish
Résumé
Microbiota derived short chain fatty acids (SCFAs) are produced by fermentation of nondigestible fiber, and are a key component in intestinal barrier homeostasis. Since the microbiome has diurnal fluctuations, we hypothesized that SCFAs in humans have a diurnal rhythm and their rhythmicity would be impacted by the host central circadian misalignment (night shift work) which would make intestinal barrier more susceptible to disruption by alcohol. To test this hypothesis, we studied 3 groups of subjects: patients with alcohol use disorder, but no liver disease (AD), healthy day workers (DW), and night workers (NW). All subjects were studied at baseline and then in DW and NW subjects after moderate daily alcohol (0.5 g/kg) for 7 days. Gut-derived plasma SCFAs showed a significant circadian oscillation by cosinor analysis in DW; however, SCFA in the AD and NW subjects lost 24-hour rhythmicity. Decrease in SCFA correlated with increased colonic permeability. Both chronic and moderate alcohol consumption for 1 week caused circadian disruption based on wrist actigraphy and urinary melatonin. Our study shows that (1) gut-derived plasma SCFAs have a diurnal rhythm in humans that is impacted by the central clock of the host; (2) moderate alcohol suppresses SCFAs which was associated with increased colonic permeability; and (3) less invasive urinary 6-SM correlated and rest-activity actigraphy correlated with plasma melatonin. Future studies are needed to examine the role circadian misalignment on gut derived SCFAs as possible mechanism for loss of intestinal barrier resiliency to injurious agents like alcohol.
Identifiants
pubmed: 32376406
pii: S1931-5244(20)30067-0
doi: 10.1016/j.trsl.2020.04.004
pmc: PMC8136245
mid: NIHMS1590952
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-109Subventions
Organisme : NIAAA NIH HHS
ID : K23 AA019966
Pays : United States
Organisme : NIAAA NIH HHS
ID : R24 AA026801
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Chronobiol Int. 2015;32(7):925-33
pubmed: 26158757
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6691-8
pubmed: 26627260
Science. 2019 Sep 27;365(6460):1428-1434
pubmed: 31604271
Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G966-78
pubmed: 22241860
Chronobiol Int. 2014 Feb;31(1):37-51
pubmed: 24164100
Sci Rep. 2018 Jan 23;8(1):1395
pubmed: 29362450
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Alcohol Clin Exp Res. 2009 Oct;33(10):1836-46
pubmed: 19645728
BMJ. 2012 Jul 26;345:e4800
pubmed: 22835925
PLoS One. 2014 May 21;9(5):e97500
pubmed: 24848969
Gastroenterology. 2013 Aug;145(2):396-406.e1-10
pubmed: 23665276
Chronobiol Int. 2014 Oct;31(8):891-900
pubmed: 24927369
Chronobiol Int. 2012 Feb;29(1):35-42
pubmed: 22217099
J Sleep Res. 2005 Sep;14(3):229-37
pubmed: 16120097
Am J Ind Med. 2013 Jun;56(6):647-59
pubmed: 22911666
MethodsX. 2016 May 24;3:430-5
pubmed: 27294030
Science. 2018 Mar 16;359(6381):
pubmed: 29439024
PLoS One. 2013 Jun 18;8(6):e67102
pubmed: 23825629
Am J Physiol Regul Integr Comp Physiol. 2016 Apr 15;310(8):R759-65
pubmed: 26936778
Diabetes. 2015 Jul;64(7):2537-49
pubmed: 25735732
Alcohol Res. 2015;37(2):223-36
pubmed: 26695747
Am J Gastroenterol. 2010 Apr;105(4):842-7
pubmed: 20160712
Curr Biol. 2013 Mar 4;23(5):372-81
pubmed: 23434278
Am J Clin Nutr. 2013 Jun;97(6):1243-51
pubmed: 23615830
J Nutr. 2009 Sep;139(9):1619-25
pubmed: 19625695
JAMA. 2013 Apr 3;309(13):1388-96
pubmed: 23549584
J Immunol. 2012 Mar 15;188(6):2583-91
pubmed: 22308312
Curr Opin Endocrinol Diabetes Obes. 2016 Oct;23(5):353-9
pubmed: 27584008
Sleep. 1998 Dec 15;21(8):871-81
pubmed: 9871949
Chronobiol Int. 2016;33(8):1101-19
pubmed: 27308960
Clin Endocrinol (Oxf). 1987 Oct;27(4):445-52
pubmed: 3436070
Am J Physiol Gastrointest Liver Physiol. 2015 Jun 15;308(12):G1004-11
pubmed: 25907689
J Clin Endocrinol Metab. 1981 Sep;53(3):645-50
pubmed: 7263845
Eur J Cancer. 2012 Jul;48(11):1722-9
pubmed: 21852111
FASEB J. 2016 Nov;30(11):3759-3770
pubmed: 27488122
J Biol Rhythms. 1997 Oct;12(5):457-66
pubmed: 9376644
Methods Mol Biol. 2018;1730:247-256
pubmed: 29363078
PLoS One. 2013 Sep 05;8(9):e73785
pubmed: 24040068
Curr Biol. 2016 Jul 25;26(14):1843-53
pubmed: 27426518
Gut. 2006 Oct;55(10):1512-20
pubmed: 16966705
Endocrinology. 2005 Dec;146(12):5092-9
pubmed: 16123168
Cell. 2014 Oct 23;159(3):514-29
pubmed: 25417104
Am J Physiol Gastrointest Liver Physiol. 2018 Jan 01;314(1):G131-G141
pubmed: 29074484
Acta Physiol (Oxf). 2019 Mar;225(3):e13193
pubmed: 30269420
J Biol Rhythms. 1997 Jun;12(3):278-89
pubmed: 9181439
Science. 2005 May 13;308(5724):1043-5
pubmed: 15845877
J Biol Rhythms. 2008 Aug;23(4):374-6
pubmed: 18663244
J Pineal Res. 2006 Mar;40(2):116-24
pubmed: 16441548
Science. 1980 Dec 12;210(4475):1267-9
pubmed: 7434030
J Gastroenterol Hepatol. 2017 Sep;32(9):1587-1597
pubmed: 28087985
Chronobiologia. 1979 Oct-Dec;6(4):305-23
pubmed: 548245
BMC Microbiol. 2014 Sep 16;14:240
pubmed: 25223989
Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G192-201
pubmed: 27198191
Trends Pharmacol Sci. 2013 Apr;34(4):226-32
pubmed: 23489932
PLoS Comput Biol. 2010 Nov 11;6(11):e1000996
pubmed: 21085644
Cell Host Microbe. 2015 May 13;17(5):681-9
pubmed: 25891358
Theor Biol Med Model. 2014 Apr 11;11:16
pubmed: 24725531
Chronobiol Int. 2011 Oct;28(8):714-8
pubmed: 21823817
J R Soc Interface. 2018 Feb;15(139):
pubmed: 29436510
BMJ. 2018 Nov 21;363:k4641
pubmed: 30464025
Cell. 2016 Dec 1;167(6):1495-1510.e12
pubmed: 27912059
Sleep Med. 2018 Dec;52:188-195
pubmed: 30243610
Oncol Res. 2017 May 24;25(5):709-719
pubmed: 27983919
Chronobiol Int. 1989;6(1):93-102
pubmed: 2706705
J Nutr. 2013 Dec;143(12):1872-81
pubmed: 24132573
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):1-11
pubmed: 16884842
J Clin Sleep Med. 2008 Feb 15;4(1):66-9
pubmed: 18350967
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12548-12553
pubmed: 29109286
Sleep Med. 2003 Mar;4(2):95-7
pubmed: 14592339
Sleep. 2015 Jun 01;38(6):889-97
pubmed: 25409110
JCI Insight. 2019 Sep 19;4(18):
pubmed: 31430260
Ann Intern Med. 1999 Oct 5;131(7):485-91
pubmed: 10507956
Inflamm Bowel Dis. 2010 Jul;16(7):1138-48
pubmed: 20024905
Ann N Y Acad Sci. 2012 Jul;1258:52-9
pubmed: 22731715
Clin Chim Acta. 1985 Aug 30;150(3):221-5
pubmed: 4064329
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 15;877(8-9):719-24
pubmed: 19230798
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84
pubmed: 26240359