BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
06 05 2020
06 05 2020
Historique:
received:
25
03
2019
revised:
13
03
2020
accepted:
16
04
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from neonatal sepsis in human newborns, but the underlying mechanism for this rapid protection is unknown. We found that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration. This was necessary and sufficient to drive emergency granulopoiesis (EG), resulting in a marked increase in neutrophils. This increase in neutrophils was directly and quantitatively responsible for protection from sepsis. Rapid induction of EG after BCG administration also occurred in three independent cohorts of human neonates.
Identifiants
pubmed: 32376769
pii: 12/542/eaax4517
doi: 10.1126/scitranslmed.aax4517
pmc: PMC8008103
mid: NIHMS1682745
pii:
doi:
Substances chimiques
Granulocyte Colony-Stimulating Factor
143011-72-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400052C
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118608
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201800047C
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD097081
Pays : United States
Organisme : Medical Research Council
ID : MR/R005990/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R005990/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17221
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U01 AI124284
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM128452
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD089939
Pays : United States
Investigateurs
Amy H Lee
(AH)
Tue B Bennike
(TB)
Joann Diray-Arce
(J)
Olubukola Idoko
(O)
William S Pomat
(WS)
Simon van Haren
(S)
Momoudou Cox
(M)
Alansana Darboe
(A)
Reza Falsafi
(R)
Samuel H Hinshaw
(SH)
Jorjoh Ndure
(J)
Jainaba Njie-Jobe
(J)
Matthew A Pettengill
(MA)
Arnaud Marchant
(A)
Peter C Richmond
(PC)
Rebecca Ford
(R)
Gerard Saleu
(G)
Geraldine Masiria
(G)
John Paul Matlam
(JP)
Wendy Kirarock
(W)
Elishia Roberts
(E)
Mehrnoush Malek
(M)
Guzman Sanchez-Schmitz
(G)
Amrit Singh
(A)
Asimenia Angelidou
(A)
Kinga K Smolen
(KK)
Ryan R Brinkman
(RR)
Al Ozonoff
(A)
Robert E W Hancock
(REW)
Anita H J van den Biggelaar
(AHJ)
Hanno Steen
(H)
Diana Vo
(D)
Ken Kraft
(K)
Kerry McEnaney
(K)
Sofia Vignolo
(S)
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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