Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1.

CD8-Positive T-Lymphocytes HIV-1 Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Humans Transplantation, Homologous

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
06 05 2020
Historique:
received: 11 09 2019
accepted: 07 04 2020
entrez: 8 5 2020
pubmed: 8 5 2020
medline: 24 6 2021
Statut: ppublish

Résumé

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only medical intervention that has led to an HIV cure. Whereas the HIV reservoir sharply decreases after allo-HSCT, the dynamics of the T cell reconstitution has not been comprehensively described. We analyzed the activation and differentiation of CD4

Identifiants

DOI: 10.1126/scitranslmed.aay9355 PMID: 32376772
pubmed: 32376772
pii: 12/542/eaay9355
doi: 10.1126/scitranslmed.aay9355
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Johanna M Eberhard (JM)

1. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.
DZIF Partner Site (German Center for Infection Research), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany.
ORCID: 0000-0002-8367-3870

Mathieu Angin (M)

Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.
ORCID: 0000-0002-6867-4680

Caroline Passaes (C)

Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.
ORCID: 0000-0002-0813-2521

Maria Salgado (M)

AIDS Research Institute IrsiCaixa, 08916 Badalona, Spain.
ORCID: 0000-0003-1551-7216

Valerie Monceaux (V)

Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.

Elena Knops (E)

Institute of Virology, University of Cologne, 50935 Cologne, Germany.
ORCID: 0000-0001-7398-3026

Guido Kobbe (G)

Department of Haematology, Oncology, and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
ORCID: 0000-0002-9745-8813

Björn Jensen (B)

Department of Gastroenterology, Hepatology, and Infectious Diseases, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
ORCID: 0000-0003-1626-4855

Maximilian Christopeit (M)

Department of Stem Cell Transplantation, University Medical Center HamburgEppendorf, 20246 Hamburg, Germany.
ORCID: 0000-0003-4627-0412

Nicolaus Kröger (N)

Department of Stem Cell Transplantation, University Medical Center HamburgEppendorf, 20246 Hamburg, Germany.

Linos Vandekerckhove (L)

HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, B-9000 Ghent, Belgium.

Jon Badiola (J)

Hematology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain.
ORCID: 0000-0003-0660-9186

Alessandra Bandera (A)

San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, Italy.
ORCID: 0000-0001-9440-4601

Kavita Raj (K)

Department of Haematology, King's College Hospital, London SE5 9RS, UK.

Jan van Lunzen (J)

1. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.
ViiV Healthcare, Brentford, Middlesex TW8 9GS, UK.

Gero Hütter (G)

Cellex, 01307 Dresden, Germany.

Jürgen H E Kuball (JHE)

University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.
ORCID: 0000-0002-3914-7806

Carolina Martinez-Laperche (C)

Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.
ORCID: 0000-0001-6802-3485

Pascual Balsalobre (P)

Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.

Mi Kwon (M)

Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.
ORCID: 0000-0002-3855-7774

José L Díez-Martín (JL)

Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.

Monique Nijhuis (M)

University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.
ORCID: 0000-0001-6610-8282

Annemarie Wensing (A)

University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.
ORCID: 0000-0003-3790-8891

Javier Martinez-Picado (J)

AIDS Research Institute IrsiCaixa, 08916 Badalona, Spain.
UVic-UCC, 08500 Vic, Spain.
ICREA, 08010 Barcelona, Spain.
ORCID: 0000-0002-4916-2129

Julian Schulze Zur Wiesch (J)

1. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany. asier.saez-cirion@pasteur.fr julianszw@gmail.com.
DZIF Partner Site (German Center for Infection Research), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany.
ORCID: 0000-0002-5033-1938

Asier Sáez-Cirión (A)

Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France. asier.saez-cirion@pasteur.fr julianszw@gmail.com.
ORCID: 0000-0003-2406-7536

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Vulnerability to reservoir reseeding due to...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Vulnerability to reservoir reseeding due to...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Tumeurs hématologiques › Vulnerability to reservoir reseeding due to...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Vulnerability to reservoir reseeding due to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vulnerability to reservoir reseeding due to...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › Vulnerability to reservoir reseeding due to...