Value-Related Neuronal Responses in the Human Amygdala during Observational Learning.
decision making
human electrophysiology
intracranial recordings
observational learning
reinforcement learning
social cognition
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
10 06 2020
10 06 2020
Historique:
received:
05
12
2019
revised:
25
03
2020
accepted:
25
04
2020
pubmed:
8
5
2020
medline:
30
10
2020
entrez:
8
5
2020
Statut:
ppublish
Résumé
The amygdala plays an important role in many aspects of social cognition and reward learning. Here, we aimed to determine whether human amygdala neurons are involved in the computations necessary to implement learning through observation. We performed single-neuron recordings from the amygdalae of human neurosurgical patients (male and female) while they learned about the value of stimuli through observing the outcomes experienced by another agent interacting with those stimuli. We used a detailed computational modeling approach to describe patients' behavior in the task. We found a significant proportion of amygdala neurons whose activity correlated with both expected rewards for oneself and others, and in tracking outcome values received by oneself or other agents. Additionally, a population decoding analysis suggests the presence of information for both observed and experiential outcomes in the amygdala. Encoding and decoding analyses suggested observational value coding in amygdala neurons occurred in a different subset of neurons than experiential value coding. Collectively, these findings support a key role for the human amygdala in the computations underlying the capacity for learning through observation.
Identifiants
pubmed: 32376780
pii: JNEUROSCI.2897-19.2020
doi: 10.1523/JNEUROSCI.2897-19.2020
pmc: PMC7294800
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4761-4772Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094258
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110831
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111425
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
Références
Cell Rep. 2017 Jan 24;18(4):878-891
pubmed: 28122239
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16012-7
pubmed: 26668400
Neuron. 2007 Aug 16;55(4):545-55
pubmed: 17698008
J Neurophysiol. 1996 May;75(5):1806-14
pubmed: 8734581
J Neurosci. 2017 Feb 22;37(8):2186-2202
pubmed: 28123082
J Neurophysiol. 2016 Jun 1;115(6):3195-203
pubmed: 27052578
Front Hum Neurosci. 2013 Jun 26;7:301
pubmed: 23805092
Nat Neurosci. 2000 Sep;3(9):946-53
pubmed: 10966627
Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):8043-8048
pubmed: 30012600
Nat Neurosci. 2005 Dec;8(12):1704-11
pubmed: 16286932
PLoS Comput Biol. 2019 Jun 18;15(6):e1007043
pubmed: 31211783
Nature. 1998 Jun 4;393(6684):470-4
pubmed: 9624002
Cogn Sci. 2014 Aug;38(6):1024-77
pubmed: 25087578
J Neurosci. 2008 Oct 1;28(40):10023-30
pubmed: 18829960
Science. 2003 Aug 22;301(5636):1104-7
pubmed: 12934011
Brain Res. 1980 May 26;190(2):347-68
pubmed: 6768425
J Neurosci Methods. 2006 Jun 30;154(1-2):204-24
pubmed: 16488479
PLoS Comput Biol. 2013;9(2):e1002918
pubmed: 23436990
Neuron. 1997 May;18(5):753-65
pubmed: 9182800
Ann N Y Acad Sci. 2010 Mar;1191:42-61
pubmed: 20392275
Neuron. 2019 Aug 7;103(3):533-545.e5
pubmed: 31196672
Brain. 2019 Nov 1;142(11):3530-3549
pubmed: 31549164
J Neurosci. 2006 Aug 9;26(32):8360-7
pubmed: 16899731
Annu Rev Neurosci. 2012;35:287-308
pubmed: 22462543
J Neurophysiol. 2007 Feb;97(2):1671-83
pubmed: 17093126
Curr Opin Neurobiol. 2004 Apr;14(2):148-55
pubmed: 15082318
Hum Brain Mapp. 2016 Nov;37(11):3979-3998
pubmed: 27354150
J Neurosci. 2000 Jun 1;20(11):4311-9
pubmed: 10818166
Neuron. 2020 Aug 19;107(4):703-716.e4
pubmed: 32521223
Front Neuroinform. 2013 May 22;7:8
pubmed: 23734125
Annu Rev Psychol. 2017 Jan 3;68:73-100
pubmed: 27687119
Trends Cogn Sci. 2007 Nov;11(11):489-97
pubmed: 17988930
Trends Neurosci. 2015 May;38(5):295-306
pubmed: 25847686
J Cogn Neurosci. 2012 Jan;24(1):106-18
pubmed: 21812568
Nat Neurosci. 2015 Jul;18(7):1041-50
pubmed: 26053402
Soc Neurosci. 2018 Dec;13(6):637-647
pubmed: 30173633
Nat Commun. 2016 Sep 06;7:12722
pubmed: 27598687
Cell. 2019 May 2;177(4):986-998.e15
pubmed: 30982599
Neuron. 2003 Aug 28;39(5):855-67
pubmed: 12948451
J Neurosci. 1999 Jul 1;19(13):5473-81
pubmed: 10377356
J Neurosci. 1997 Aug 1;17(15):6011-20
pubmed: 9221797
Neuroscience. 2005;131(1):1-11
pubmed: 15680687
Nat Commun. 2017 Apr 21;8:14821
pubmed: 28429707
Neural Netw. 1999 Oct;12(7-8):961-974
pubmed: 12662639
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3788-92
pubmed: 20142490
Neuroimage. 2014 Jan 1;84:971-85
pubmed: 24018303
J Neurosci. 2017 Aug 30;37(35):8374-8384
pubmed: 28743727
Annu Rev Neurosci. 2010;33:173-202
pubmed: 20331363