Hypothalamic estrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure.

Animals Energy Metabolism Estrogen Receptor alpha / metabolism Female Fluorescent Dyes / chemistry Genetic Markers Hypothalamus / cytology Male Mice Neurons / metabolism Sex Characteristics

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
04 2020
Historique:
entrez: 8 5 2020
pubmed: 8 5 2020
medline: 8 5 2020
Statut: ppublish

Résumé

Estrogen receptor a (ERa) signaling in the ventromedial hypothalamus (VMH) contributes to energy homeostasis by modulating physical activity and thermogenesis. However, the precise neuronal populations involved remain undefined. Here, we describe six neuronal populations in the mouse VMH by using single-cell RNA transcriptomics and in situ hybridization. ERa is enriched in populations showing sex biased expression of reprimo (

Identifiants

DOI: 10.1038/s42255-020-0189-6 PMID: 32377634 PMC: PMC7202561
pubmed: 32377634
doi: 10.1038/s42255-020-0189-6
pmc: PMC7202561
mid: NIHMS1576083
doi:

Substances chimiques

Estrogen Receptor alpha 0
Fluorescent Dyes 0
Genetic Markers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Pagination

351-363

Subventions

Organisme : NIDDK NIH HHS
ID : K01 DK098320
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD076125
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG051381
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026914
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States

Déclaration de conflit d'intérêts

Competing Interests Statement The authors declare no competing interests.

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Auteurs

J Edward van Veen (JE)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA.
authors contributed equally.

Laura G Kammel (LG)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA.
Molecular, Cellular, and Integrative Physiology Graduate Program, University of California, Los Angeles, CA, USA.
authors contributed equally.

Patricia C Bunda (PC)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Michael Shum (M)

Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Molecular Biology Institute, University of California, Los Angeles, CA, USA.

Michelle S Reid (MS)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Megan G Massa (MG)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA.
Neuroscience Interdepartmental Doctoral Program, University of California, Los Angeles, CA, USA.

Douglas Arneson (D)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Jae W Park (JW)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Zhi Zhang (Z)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA.

Alexia M Joseph (AM)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Haley Hrncir (H)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Marc Liesa (M)

Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Molecular Biology Institute, University of California, Los Angeles, CA, USA.

Arthur P Arnold (AP)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA.

Xia Yang (X)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Stephanie M Correa (SM)

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur alpha des oestrogènes › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Marqueurs génétiques › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Cellules › Neurones › Hypothalamic estrogen receptor alpha...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Hypothalamic estrogen receptor alpha...