Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.
Antineoplastic Agents
/ therapeutic use
Arginine
/ metabolism
Cardiovascular Diseases
/ enzymology
Enzyme Inhibitors
/ therapeutic use
Epigenesis, Genetic
Histones
/ genetics
Humans
Metabolic Diseases
/ enzymology
Methylation
Neoplasms
/ drug therapy
Protein Processing, Post-Translational
Protein-Arginine N-Methyltransferases
/ antagonists & inhibitors
RNA Splicing
Signal Transduction
Transcription Factors
/ antagonists & inhibitors
PRMT
PRMT inhibitor
arginine methylation
cancer
epigenetic modifications
non-histone protein
Journal
Current protein & peptide science
ISSN: 1875-5550
Titre abrégé: Curr Protein Pept Sci
Pays: United Arab Emirates
ID NLM: 100960529
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
08
2019
revised:
17
09
2019
accepted:
27
09
2019
pubmed:
8
5
2020
medline:
5
2
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent posttransitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and how PRMT-mediated non-histone arginine methylation modulates various diseases. Additionally, we highlight the most recent clinical studies for several PRMT inhibitors.
Identifiants
pubmed: 32379587
pii: CPPS-EPUB-106429
doi: 10.2174/1389203721666200507091952
pmc: PMC7529871
mid: NIHMS1594793
doi:
Substances chimiques
Antineoplastic Agents
0
Enzyme Inhibitors
0
Histones
0
Transcription Factors
0
Arginine
94ZLA3W45F
Protein-Arginine N-Methyltransferases
EC 2.1.1.319
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-712Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM117275
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA214649
Pays : United States
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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