Unwind and Relax: DDX3X RNA Helicase as a Critical Mediator of Cortical Neurogenesis.

DEAD-box RNA Helicases / genetics Fetal Development Humans Mutation Neurogenesis RNA

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
06 05 2020
Historique:
entrez: 8 5 2020
pubmed: 8 5 2020
medline: 13 8 2020
Statut: ppublish

Résumé

In this issue of Neuron, Lennox et al. (2020) report the largest cohort of patients to date with DDX3X syndrome, discovering unique genotype-phenotype relationships that inform molecular pathogenesis. They then uncover unique roles of DDX3X in cortical neuron development and ribonucleoprotein granule formation.

Identifiants

DOI: 10.1016/j.neuron.2020.03.035 PMID: 32380046
pubmed: 32380046
pii: S0896-6273(20)30242-7
doi: 10.1016/j.neuron.2020.03.035
pii:
doi:

Substances chimiques

RNA 63231-63-0
DDX3X protein, human EC 3.6.1.-
DEAD-box RNA Helicases EC 3.6.4.13

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

357-358

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Blake Vuocolo (B)

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Department of Pediatrics, Division of Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, TX, USA.

J Lloyd Holder (JL)

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Department of Pediatrics, Division of Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, TX, USA. Electronic address: holder@bcm.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › DEAD-box RNA helicases › Unwind and Relax: DDX3X RNA Helicase as a...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement foetal › Unwind and Relax: DDX3X RNA Helicase as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Unwind and Relax: DDX3X RNA Helicase as a...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Unwind and Relax: DDX3X RNA Helicase as a...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Unwind and Relax: DDX3X RNA Helicase as a...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Unwind and Relax: DDX3X RNA Helicase as a...