Granulocyte-targeted therapies for airway diseases.
Acute lower respiratory tract infections
Asthma
Chronic obstructive pulmonary disease
Granulocytes
Inflammation
Targeted therapy in the lungs
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
26
04
2020
accepted:
27
04
2020
pubmed:
8
5
2020
medline:
1
6
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
The average respiration rate for an adult is 12-20 breaths per minute, which constantly exposes the lungs to allergens and harmful particles. As a result, respiratory diseases, which includes asthma, chronic obstructive pulmonary disease (COPD) and acute lower respiratory tract infections (LTRI), are a major cause of death worldwide. Although asthma, COPD and LTRI are distinctly different diseases with separate mechanisms of disease progression, they do share a common feature - airway inflammation with intense recruitment and activation of granulocytes and mast cells. Neutrophils, eosinophils, basophils, and mast cells are crucial players in host defense against pathogens and maintenance of lung homeostasis. Upon contact with harmful particles, part of the pulmonary defense mechanism is to recruit these cells into the airways. Despite their protective nature, overactivation or accumulation of granulocytes and mast cells in the lungs results in unwanted chronic airway inflammation and damage. As such, understanding the bright and the dark side of these leukocytes in lung physiology paves the way for the development of therapies targeting this important mechanism of disease. Here we discuss the role of granulocytes in respiratory diseases and summarize therapeutic strategies focused on granulocyte recruitment and activation in the lungs.
Identifiants
pubmed: 32380052
pii: S1043-6618(20)31189-0
doi: 10.1016/j.phrs.2020.104881
pmc: PMC7198161
pii:
doi:
Substances chimiques
Inflammation Mediators
0
Respiratory System Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104881Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declared no conflict of interests.
Références
Chest. 2017 Dec;152(6):1276-1282
pubmed: 28583618
FEBS J. 2016 Apr;283(8):1465-74
pubmed: 26881904
Am J Respir Cell Mol Biol. 2016 Sep;55(3):387-94
pubmed: 27049514
Front Pharmacol. 2017 Dec 22;8:947
pubmed: 29311944
Lancet. 2015 Apr 18;385(9977):1511-8
pubmed: 25608756
Chest. 2007 Jul;132(1):98-105
pubmed: 17550933
J Clin Med. 2018 Aug 28;7(9):
pubmed: 30154365
Am Rev Respir Dis. 1993 Sep;148(3):713-9
pubmed: 8368644
Nat Commun. 2019 Jul 31;10(1):3422
pubmed: 31366921
Inflamm Res. 2009 Oct;58(10):631-8
pubmed: 19440657
Nat Rev Immunol. 2016 Jan;16(1):51-67
pubmed: 26688348
Clin Exp Allergy. 1989 Mar;19(2):143-55
pubmed: 2473830
Drug Saf. 2017 Jul;40(7):559-570
pubmed: 28321782
Am J Pathol. 2011 Jul;179(1):199-210
pubmed: 21703402
Int J Chron Obstruct Pulmon Dis. 2018 Oct 12;13:3341-3348
pubmed: 30349237
Am J Respir Cell Mol Biol. 2003 Jan;28(1):12-24
pubmed: 12495928
N Engl J Med. 1998 May 28;338(22):1592-600
pubmed: 9603798
Eur J Clin Microbiol Infect Dis. 2019 Dec;38(12):2341-2348
pubmed: 31463620
J Allergy Clin Immunol. 2009 May;123(5):1185-7
pubmed: 19361847
Am J Respir Crit Care Med. 2013 Dec 1;188(11):1294-302
pubmed: 24200404
J Allergy Clin Immunol. 2020 Jan;145(1):335-344
pubmed: 31622689
FASEB J. 2020 Feb;34(2):2749-2764
pubmed: 31908042
J Allergy Clin Immunol. 2019 Jan;143(1):135-141
pubmed: 29906525
Adv Exp Med Biol. 2014;844:99-113
pubmed: 25480639
J Clin Invest. 2016 Sep 1;126(9):3279-95
pubmed: 27548519
Annu Rev Physiol. 2014;76:467-92
pubmed: 24313723
J Immunol. 2013 May 1;190(9):4676-84
pubmed: 23526820
Lancet. 2017 Sep 16;390(10100):1151-1210
pubmed: 28919116
Lancet Respir Med. 2014 Nov;2(11):879-890
pubmed: 25306557
J Allergy Clin Immunol. 2007 Jun;119(6):1303-10; quiz 1311-2
pubmed: 17481712
Clin Nucl Med. 2004 Dec;29(12):803-4
pubmed: 15545884
J Immunol. 2017 Apr 15;198(8):3214-3226
pubmed: 28283567
J Biol Chem. 2011 Sep 23;286(38):32899-905
pubmed: 21799015
Am J Respir Cell Mol Biol. 2003 Sep;29(3 Pt 1):405-9
pubmed: 12702544
Arch Dis Child. 2003 Oct;88(10):922-6
pubmed: 14500316
Microbiol Spectr. 2016 Aug;4(4):
pubmed: 27726791
Thorax. 2013 Apr;68(4):322-9
pubmed: 23291349
Clin Pharmacol Ther. 2018 Dec;104(6):1155-1164
pubmed: 29484635
Inflamm Res. 2017 Apr;66(4):283-302
pubmed: 27744631
Allergy. 2015 Sep;70(9):1184-8
pubmed: 26043360
J Immunol. 2009 Dec 1;183(11):7441-50
pubmed: 19917678
J Allergy Clin Immunol. 2004 Jul;114(1):174-82
pubmed: 15241362
N Engl J Med. 2009 Mar 5;360(10):1002-14
pubmed: 19264689
Expert Opin Pharmacother. 2017 Jul;18(10):973-988
pubmed: 28480770
Chest. 2008 Sep;134(3):606-612
pubmed: 18779195
BMC Microbiol. 2012 May 15;12:73
pubmed: 22587610
Immunol Rev. 2018 Mar;282(1):151-167
pubmed: 29431215
Front Cell Neurosci. 2019 Jul 03;13:299
pubmed: 31333418
J Thorac Dis. 2016 Mar;8(3):E162-71
pubmed: 27076965
Mediators Inflamm. 2012;2012:649570
pubmed: 22719178
BMC Pharmacol Toxicol. 2015 Jun 20;16:18
pubmed: 26092545
Am J Respir Crit Care Med. 2019 Nov 15;200(10):1282-1293
pubmed: 31206313
Front Immunol. 2017 May 12;8:550
pubmed: 28553293
N Engl J Med. 2000 May 4;342(18):1334-49
pubmed: 10793167
J Appl Physiol (1985). 1987 Mar;62(3):1236-43
pubmed: 3106311
Indian J Pediatr. 2016 Apr;83(4):345-53
pubmed: 26865172
BMJ. 2011 Apr 06;342:d1642
pubmed: 21471172
Clin Sci (Lond). 2017 Jul 1;131(13):1541-1558
pubmed: 28659395
Respir Res. 2019 Jan 18;20(1):14
pubmed: 30658649
J Investig Allergol Clin Immunol. 2009;19(5):340-54
pubmed: 19862934
Eur Respir J. 2007 Nov;30(5):951-6
pubmed: 17690125
Nat Rev Immunol. 2013 Jan;13(1):9-22
pubmed: 23154224
Nat Rev Immunol. 2003 Sep;3(9):733-44
pubmed: 12949497
Blood. 2014 Jan 30;123(5):743-52
pubmed: 24297871
J Leukoc Biol. 2018 Jul;104(1):85-93
pubmed: 29749658
Cell. 2018 Nov 1;175(4):1031-1044.e18
pubmed: 30318149
N Engl J Med. 2013 Jun 27;368(26):2455-66
pubmed: 23688323
J Clin Invest. 2019 Jun 17;129(7):2629-2639
pubmed: 31205028
Open Forum Infect Dis. 2019 Mar 07;6(4):ofz106
pubmed: 31041337
Nat Med. 2012 May 04;18(5):716-25
pubmed: 22561835
Mucosal Immunol. 2010 May;3(3):270-9
pubmed: 20130564
Lancet. 2006 Aug 26;368(9537):804-13
pubmed: 16935691
Science. 2015 Sep 4;349(6252):aaa4352
pubmed: 26339033
Blood. 2003 Oct 1;102(7):2660-9
pubmed: 12829592
J Immunol. 1998 Feb 1;160(3):1279-84
pubmed: 9570544
Mucosal Immunol. 2016 Sep;9(5):1278-87
pubmed: 26647716
J Allergy Clin Immunol. 2003 Mar;111(3):450-63; quiz 464
pubmed: 12642820
Immunol Rev. 2001 Feb;179:182-91
pubmed: 11292022
BMJ. 2009 Jun 16;338:b2137
pubmed: 19531550
Pediatr Int. 2005 Apr;47(2):190-5
pubmed: 15771699
Biomed Res Int. 2018 Jan 28;2018:9095275
pubmed: 29619379
Cell. 2013 Jul 3;154(1):197-212
pubmed: 23827683
Cell Tissue Res. 2018 Mar;371(3):577-588
pubmed: 29250746
Int J Infect Dis. 2020 May;94:128-132
pubmed: 32251805
Trends Immunol. 2013 Aug;34(8):398-409
pubmed: 23665135
Curr Mol Med. 2008 Sep;8(6):585-90
pubmed: 18781965
Am J Respir Crit Care Med. 2008 Sep 15;178(6):574-82
pubmed: 18583575
J Transl Med. 2020 May 20;18(1):206
pubmed: 32434518
Exp Dermatol. 1999 Feb;8(1):1-16
pubmed: 10206716
Chest. 2017 Aug;152(2):249-262
pubmed: 28442313
Front Immunol. 2018 Oct 02;9:2275
pubmed: 30333833
Eur J Pharmacol. 2016 May 5;778:90-5
pubmed: 25959388
Thorax. 2015 Aug;70(8):748-56
pubmed: 26001563
Nature. 2008 Jul 24;454(7203):445-54
pubmed: 18650915
Thorax. 2003 Jun;58(6):500-4
pubmed: 12775860
Front Immunol. 2014 Nov 14;5:569
pubmed: 25452755
Front Biosci. 2001 Sep 01;6:D1109-27
pubmed: 11532608
Cochrane Database Syst Rev. 2017 Dec 13;12:CD007720
pubmed: 29236286
Monaldi Arch Chest Dis. 2012 Jun;77(2):94-101
pubmed: 23193846
Mucosal Immunol. 2015 Jul;8(4):852-62
pubmed: 25465102
Front Immunol. 2018 Nov 26;9:2763
pubmed: 30534130
Am J Respir Crit Care Med. 2004 Dec 15;170(12):1331-9
pubmed: 15361366
Nat Rev Immunol. 2008 Mar;8(3):193-204
pubmed: 18301423
N Engl J Med. 1998 Feb 12;338(7):436-45
pubmed: 9459648
Front Public Health. 2013 Jun 21;1:19
pubmed: 24350188
Elife. 2019 Oct 15;8:
pubmed: 31613219
Nanomedicine. 2016 Nov;12(8):2415-2427
pubmed: 27381067
Respir Res. 2018 Apr 4;19(1):55
pubmed: 29615049
Arch Intern Med. 1998 Jun 8;158(11):1213-20
pubmed: 9625400
Clin Exp Immunol. 2002 Oct;130(1):93-100
pubmed: 12296858
mBio. 2016 Sep 13;7(5):
pubmed: 27624128
Curr Opin Immunol. 2018 Oct;54:74-79
pubmed: 29960953
J Exp Med. 2018 Nov 5;215(11):2778-2795
pubmed: 30282719
Clin Infect Dis. 2012 Dec;55(11):1466-73
pubmed: 22918991
Pediatrics. 2006 Aug;118(2):644-50
pubmed: 16882819
J Immunol. 2012 Jan 15;188(2):536-40
pubmed: 22156496
F1000Res. 2019 Apr 26;8:
pubmed: 31069060
PLoS One. 2019 Jan 4;14(1):e0210188
pubmed: 30608978
Immunol Rev. 2018 Mar;282(1):35-46
pubmed: 29431204
FASEB J. 2019 Nov;33(11):12188-12199
pubmed: 31398292
Am J Respir Crit Care Med. 2010 Jun 15;181(12):1294-309
pubmed: 20167850
Lancet Respir Med. 2018 Jul;6(7):511-525
pubmed: 29792288
Lancet. 2013 Oct 19;382(9901):1360-72
pubmed: 24041942
Lancet Respir Med. 2016 Oct;4(10):797-806
pubmed: 27574788
Int J Mol Sci. 2018 Dec 17;19(12):
pubmed: 30563002
Nat Rev Immunol. 2002 Oct;2(10):773-86
pubmed: 12360215
Immunol Rev. 2010 Jul;236:28-40
pubmed: 20636806
Nat Rev Drug Discov. 2005 Dec;4(12):977-87
pubmed: 16341063
Antimicrob Agents Chemother. 2018 Apr 26;62(5):
pubmed: 29463546
Curr Probl Cancer. 2015 Sep-Oct;39(5):287-91
pubmed: 26433765
COPD. 2018 Jun-Aug;15(4):392-404
pubmed: 30064276
Chest. 2016 Sep;150(3):680-93
pubmed: 27316557
Am J Respir Crit Care Med. 1999 Oct;160(4):1079-100
pubmed: 10508792
Clin Rev Allergy Immunol. 2019 Apr;56(2):219-233
pubmed: 30206782
J Allergy Clin Immunol. 2006 Feb;117(2):269-74
pubmed: 16461126
Respir Res. 2018 Sep 20;19(1):180
pubmed: 30236095
Curr Opin Immunol. 2007 Dec;19(6):681-6
pubmed: 17949963
J Immunol. 2002 Jul 15;169(2):1021-7
pubmed: 12097410
Front Immunol. 2017 Dec 13;8:1799
pubmed: 29326698
Clin Chest Med. 2012 Sep;33(3):559-70
pubmed: 22929102
Int J Infect Dis. 2020 Jun;95:183-191
pubmed: 32173576
Blood Adv. 2018 Sep 11;2(17):2273-2281
pubmed: 30206100
Cancer Cell. 2009 Sep 8;16(3):183-94
pubmed: 19732719
Lancet. 2010 Sep 4;376(9743):750-1
pubmed: 20816529
Cytokine. 2015 Sep;75(1):25-37
pubmed: 26073683
N Engl J Med. 2001 Feb 1;344(5):350-62
pubmed: 11172168
Blood. 1978 Sep;52(3):609-17
pubmed: 678676
Lancet Infect Dis. 2018 Nov;18(11):1191-1210
pubmed: 30243584
Front Cell Infect Microbiol. 2017 May 01;7:160
pubmed: 28507954
PLoS Pathog. 2015 Aug 27;11(8):e1005126
pubmed: 26313746
Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1532-9
pubmed: 10556116
J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):531-8
pubmed: 9802359
Lancet Respir Med. 2013 Oct;1(8):639-652
pubmed: 24461667
N Engl J Med. 2009 Mar 5;360(10):973-84
pubmed: 19264686
Immunol Lett. 2014 May-Jun;159(1-2):11-4
pubmed: 24534641
Clin Rev Allergy Immunol. 2020 Jun;58(3):377-387
pubmed: 32086776
Allergy. 2018 Dec;73(12):2342-2351
pubmed: 29777594
Eur Respir J. 2018 Apr 12;51(4):
pubmed: 29449427
Immunity. 2009 Sep 18;31(3):412-24
pubmed: 19766084
Expert Opin Biol Ther. 2012 Jan;12(1):113-8
pubmed: 22136436
J Allergy Clin Immunol. 2014 Mar;133(3):921-3
pubmed: 24418480
Am J Respir Cell Mol Biol. 2008 Nov;39(5):543-50
pubmed: 18474669
J Immunol. 2018 Apr 15;200(8):2757-2766
pubmed: 29523657
Am J Respir Crit Care Med. 2010 Apr 15;181(8):788-96
pubmed: 20056900
Thorax. 2019 Jul;74(7):659-666
pubmed: 30674586
J Exp Med. 1996 Jan 1;183(1):195-201
pubmed: 8551223
Front Pharmacol. 2017 Aug 08;8:512
pubmed: 28848433
J Pediatr. 2010 May;156(5):749-54
pubmed: 20171653
J Leukoc Biol. 2001 Nov;70(5):691-8
pubmed: 11698487
J Immunol. 2010 Jun 15;184(12):7108-15
pubmed: 20483738
Am J Respir Crit Care Med. 2005 Feb 1;171(3):242-8
pubmed: 15557131
Lancet. 2016 Oct 29;388(10056):2128-2141
pubmed: 27609406
Curr Respir Med Rev. 2014 Jun;10(2):115-123
pubmed: 25484639
Allergy. 2017 Oct;72(10):1583-1586
pubmed: 28426171
Clin Sci (Lond). 2018 May 20;132(9):959-983
pubmed: 29780024
Cardiovasc Res. 2018 Nov 1;114(13):1714-1727
pubmed: 30165574
J Virol. 2015 Feb;89(3):1564-78
pubmed: 25410867
Biochim Biophys Acta. 2012 Jan;1822(1):21-33
pubmed: 21185371
Mol Aspects Med. 2017 Dec;58:44-56
pubmed: 28455109
Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13057-13062
pubmed: 30510003
J Immunol. 2008 Dec 1;181(11):8053-67
pubmed: 19017998
Clin Exp Allergy. 2012 Jul;42(7):1097-103
pubmed: 22702508
Cold Spring Harb Perspect Biol. 2012 Dec 01;4(12):
pubmed: 23209149
PLoS One. 2017 Jul 12;12(7):e0180742
pubmed: 28704475
Clin Exp Allergy. 2000 Jun;30 Suppl 1:22-7
pubmed: 10849470
J Allergy Clin Immunol. 2012 Jan;129(1):48-59
pubmed: 22196524
Blood Transfus. 2012 Apr;10(2):148-64
pubmed: 22244003
Expert Rev Anti Infect Ther. 2018 Sep;16(9):667-677
pubmed: 30118377
Transl Res. 2016 Aug;174:60-76
pubmed: 26845625
Lancet Respir Med. 2017 Sep;5(9):747-759
pubmed: 28601554
Clin Exp Allergy. 2016 Feb;46(2):194-263
pubmed: 26567481
Eur Respir Rev. 2015 Sep;24(137):516-24
pubmed: 26324814
Immunol Rev. 2016 Sep;273(1):11-28
pubmed: 27558325
J Immunol. 2019 Mar 1;202(5):1531-1539
pubmed: 30683705
Cell Stem Cell. 2010 Apr 2;6(4):361-368
pubmed: 20362540
Clin Rev Allergy Immunol. 2020 Jun;58(3):342-365
pubmed: 31828527
Lancet. 2011 Jun 11;377(9782):2023-30
pubmed: 21636122
J Biol Chem. 2007 Jul 20;282(29):20809-15
pubmed: 17456473
Cell Host Microbe. 2014 May 14;15(5):526-36
pubmed: 24832448
Nat Rev Cancer. 2016 Jul;16(7):431-46
pubmed: 27282249
Crit Care. 2012 Jul 12;16(4):R122
pubmed: 22789037
Medicine (Baltimore). 2019 Mar;98(13):e14636
pubmed: 30921179
Front Immunol. 2012 Aug 02;3:238
pubmed: 22876248
Clin Sci (Lond). 2019 Feb 18;133(4):551-564
pubmed: 30733313
J Gen Virol. 2014 Mar;95(Pt 3):578-590
pubmed: 24323639
Nat Rev Immunol. 2009 Jan;9(1):9-13
pubmed: 19039320
Cell Death Differ. 2020 May;27(5):1451-1454
pubmed: 32205856
Blood. 2007 Sep 1;110(5):1578-86
pubmed: 17495130
J Appl Physiol (1985). 1990 Nov;69(5):1767-78
pubmed: 2272970
Lancet. 2016 Jul 2;388(10039):31-44
pubmed: 27130691
Nature. 1999 Nov 25;402(6760 Suppl):B18-23
pubmed: 10586891
Glob Health Epidemiol Genom. 2018 Apr 6;3:e4
pubmed: 29868229
Allergy. 2013 Feb;68(2):180-9
pubmed: 23205591