Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.
Adult
Aged
Aged, 80 and over
B7-H1 Antigen
/ metabolism
Gene Expression Regulation, Neoplastic
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
/ metabolism
Kaplan-Meier Estimate
Linear Models
Melanoma
/ genetics
Middle Aged
Mucous Membrane
/ pathology
Multivariate Analysis
Poly (ADP-Ribose) Polymerase-1
/ genetics
Proportional Hazards Models
Skin Neoplasms
/ genetics
Survival Analysis
Ulcer
/ pathology
Up-Regulation
/ genetics
Young Adult
IDO1
PARP
anorectal melanoma
mucosal melanoma
neoplasia
prognosis
sinonasal melanoma
vulvar melanoma
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 05 2020
05 05 2020
Historique:
received:
15
04
2020
revised:
29
04
2020
accepted:
02
05
2020
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
24
2
2021
Statut:
epublish
Résumé
Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. PARP1, PD-L1 and IDO1 immunostains were performed on 192 mucosal melanomas including 86 vulvar, 89 sinonasal, and 17 anorectal melanomas. By Kaplan-Meier analyses, high PARP1 expression correlated with worse overall and melanoma-specific survival (log-rank Increased expression of PARP1 is an independent negative prognostic marker in mucosal melanomas. The association between PARP1 and IDO1 and their combined adverse prognostic role raise the potential of combined therapy in mucosal melanoma.
Identifiants
pubmed: 32380691
pii: cells9051135
doi: 10.3390/cells9051135
pmc: PMC7290913
pii:
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
IDO1 protein, human
0
Indoleamine-Pyrrole 2,3,-Dioxygenase
0
PARP1 protein, human
EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1
EC 2.4.2.30
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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