Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus.

Animals CA1 Region, Hippocampal / metabolism Cell Adhesion Molecules, Neuronal / deficiency Excitatory Postsynaptic Potentials Immunohistochemistry Inhibitory Postsynaptic Potentials Membrane Proteins / deficiency Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins / deficiency Patch-Clamp Techniques Protein Isoforms / genetics RNA Splicing Synapses / physiology
CA1 pyramidal neuron GABA receptor excitatory and inhibitory balance glutamate receptor hippocampus neurobiology neuroligin 3 (NLGN3) neuron neurotransmitter receptor splice variants synapse synaptic transmission trans-synaptic cell adhesion

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
19 06 2020
Historique:
received: 22 01 2020
revised: 01 05 2020
pubmed: 10 5 2020
medline: 6 1 2021
entrez: 9 5 2020
Statut: ppublish

Résumé

Synapse formation is a dynamic process essential for the development and maturation of the neuronal circuitry in the brain. At the synaptic cleft, trans-synaptic protein-protein interactions are major biological determinants of proper synapse efficacy. The balance of excitatory and inhibitory synaptic transmission (E-I balance) stabilizes synaptic activity, and dysregulation of the E-I balance has been implicated in neurodevelopmental disorders, including autism spectrum disorders. However, the molecular mechanisms underlying the E-I balance remain to be elucidated. Here, using single-cell transcriptomics, immunohistochemistry, and electrophysiology approaches to murine CA1 pyramidal neurons obtained from organotypic hippocampal slice cultures, we investigate neuroligin (

Identifiants

DOI: 10.1074/jbc.AC120.012571 PMID: 32381505 PMC: PMC7307194
pubmed: 32381505
pii: S0021-9258(17)49251-9
doi: 10.1074/jbc.AC120.012571
pmc: PMC7307194
doi:

Substances chimiques

Cell Adhesion Molecules, Neuronal 0
Membrane Proteins 0
Nerve Tissue Proteins 0
Protein Isoforms 0
neuroligin 3 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8589-8595

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS085215
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM107000
Pays : United States

Informations de copyright

© 2020 Uchigashima et al.

Déclaration de conflit d'intérêts

Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.

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Auteurs

Motokazu Uchigashima (M)

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
ORCID: 0000-0002-0878-2233

Ming Leung (M)

Department of Biochemistry and Molecular Biology and Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

Takuya Watanabe (T)

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Amy Cheung (A)

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
ORCID: 0000-0002-4708-0293

Timmy Le (T)

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
ORCID: 0000-0001-9274-3570

Sabine Pallat (S)

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Alexandre Luis Marques Dinis (ALM)

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Masahiko Watanabe (M)

Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Yuka Imamura Kawasawa (YI)

Department of Biochemistry and Molecular Biology and Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA yimamura@pennstatehealth.psu.edu Kensuke.Futai@umassmed.edu.
Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
ORCID: 0000-0002-8638-6738

Kensuke Futai (K)

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA yimamura@pennstatehealth.psu.edu Kensuke.Futai@umassmed.edu.
ORCID: 0000-0002-3433-3407

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Région CA1 de l'hippocampe › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécules d'adhérence cellulaire neuronale › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques inhibiteurs › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Techniques de patch-clamp › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Neuroligin3 splice isoforms shape inhibitory...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Neuroligin3 splice isoforms shape inhibitory...