CRY1-CBS binding regulates circadian clock function and metabolism.
ARNTL Transcription Factors
/ genetics
Amino Acid Sequence
Animals
CLOCK Proteins
/ genetics
Circadian Clocks
/ genetics
Circadian Rhythm
/ genetics
Cryptochromes
/ deficiency
Cystathionine beta-Synthase
/ genetics
E-Box Elements
Female
HEK293 Cells
Humans
Male
Metabolic Networks and Pathways
/ genetics
Metabolome
/ genetics
Mice
Mice, Knockout
Mutation
Period Circadian Proteins
/ genetics
Protein Binding
Protein Processing, Post-Translational
Sequence Alignment
Sequence Homology, Amino Acid
Signal Transduction
circadian rhythm
cryptochrome
cystathionine β-synthase
metabolism
transcriptional regulation
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
01
2020
revised:
09
04
2020
accepted:
04
05
2020
pubmed:
10
5
2020
medline:
22
6
2021
entrez:
9
5
2020
Statut:
ppublish
Résumé
Circadian disruption influences metabolic health. Metabolism modulates circadian function. However, the mechanisms coupling circadian rhythms and metabolism remain poorly understood. Here, we report that cystathionine β-synthase (CBS), a central enzyme in one-carbon metabolism, functionally interacts with the core circadian protein cryptochrome 1 (CRY1). In cells, CBS augments CRY1-mediated repression of the CLOCK/BMAL1 complex and shortens circadian period. Notably, we find that mutant CBS-I278T protein, the most common cause of homocystinuria, does not bind CRY1 or regulate its repressor activity. Transgenic Cbs
Identifiants
pubmed: 32383312
doi: 10.1111/febs.15360
pmc: PMC7648728
mid: NIHMS1603497
doi:
Substances chimiques
ARNTL Transcription Factors
0
Bmal1 protein, mouse
0
Cry1 protein, mouse
0
Cry2 protein, mouse
0
Cryptochromes
0
Per1 protein, mouse
0
Period Circadian Proteins
0
CLOCK Proteins
EC 2.3.1.48
Clock protein, mouse
EC 2.3.1.48
Cystathionine beta-Synthase
EC 4.2.1.22
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
614-639Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118102
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101404
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS054794
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227485
Pays : United States
Informations de copyright
© 2020 Federation of European Biochemical Societies.
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